Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137688
Title: A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy
Authors: Wang, Dongdong
Wu, Huihui
Lim, Wei Qi
Phua, Fiona Soo Zeng
Xu, Pengping
Chen, Qianwang
Guo, Zhen
Zhao, Yanli
Keywords: Science::Chemistry
Endogenous Oxygenation
Issue Date: 2019
Source: Wang, D., Wu, H., Lim, W. Q., Phua, F. S. Z., Xu, P., Chen, Q., ... Zhao, Y. (2019). A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy. Advanced Materials, 31(27), 1901893-. doi:10.1002/adma.201901893
Journal: Advanced Materials
Abstract: Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen (1O2). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal–organic frameworks (MOFs) is presented for in situ generation of endogenous O2 to enhance the PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese-based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post-modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O2 generation through the catalytic reaction between the catalytic amount NE and the endogenous H2O2, the hypoxic tumor microenvironment is relieved. Thus, Ce6-loaded NE serves as a H2O2-activated oxygen supplier to increase the local O2 concentration for significantly enhanced antitumor PDT efficacy in vitro and in vivo. In addition, the NE also shows T2-weighted magnetic resonance imaging ability for its in vivo tracking. This work presents an interesting biomedical use of MOF-derived mesoporous NE as a multifunctional theranostic agent in cancer therapy.
URI: https://hdl.handle.net/10356/137688
ISSN: 0935-9648
DOI: 10.1002/adma.201901893
Rights: This is the peer reviewed version of the following article:Wang, D., Wu, H., Lim, W. Q., Phua, F. S. Z., Xu, P., Chen, Q., ... Zhao, Y. (2019). A mesoporous nanoenzyme derived from metal–organic frameworks with endogenous oxygen generation to alleviate tumor hypoxia for significantly enhanced photodynamic therapy. Advanced Materials, 31(27), 1901893-. doi:10.1002/adma.201901893, which has been published in final form at 10.1002/adma.201901893. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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