Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137689
Title: A hypoxia-responsive albumin-based nanosystem for deep tumor penetration and excellent therapeutic efficacy
Authors: Yang, Guangbao
Phua, Fiona Soo Zeng
Lim, Wei Qi
Zhang, Rui
Feng, Liangzhu
Liu, Guofeng
Wu, Hongwei
Bindra, Anivind Kaur
Jana, Deblin
Liu, Zhuang
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2019
Source: Yang, G., Phua, F. S. Z., Lim, W. Q., Zhang, R., Feng, L., Liu, G., ... Zhao, Y. (2019). A hypoxia-responsive albumin-based nanosystem for deep tumor penetration and excellent therapeutic efficacy. Advanced Materials, 31(25), 1901513-. doi:10.1002/adma.201901513
Journal: Advanced Materials
Abstract: Uncontrolled cancer cell proliferation, insufficient blood flow, and inadequate endogenous oxygen lead to hypoxia in tumor tissues. Herein, a unique type of hypoxia-responsive human serum albumin (HSA)-based nanosystem (HCHOA) is reported, prepared by cross-linking the hypoxia-sensitive azobenzene group between photosensitizer chlorin e6 (Ce6)-conjugated HSA (HC) and oxaliplatin prodrug-conjugated HSA (HO). The HCHOA nanosystem is stable under normal oxygen partial pressure with a size of 100–150 nm. When exposed to the hypoxic tumor microenvironment, the nanosystem can quickly dissociate into ultrasmall HC and HO therapeutic nanoparticles with a diameter smaller than 10 nm, significantly enabling their enhanced intratumoral penetration. After the dissociation, the quenched fluorescence of Ce6 in the produced HC nanoparticles can be recovered for bioimaging. At the same time, the production of singlet oxygen is increased because of the enhancement in the photoactivity of the photosensitizer. On account of these improvements, combined photodynamic therapy and chemotherapy is realized to display superior antitumor efficacy in vivo. Based on this simple strategy, it is possible to achieve the dissociation of hypoxic-responsive nanosystem to enhance the tumor penetration and therapeutic effect.
URI: https://hdl.handle.net/10356/137689
ISSN: 0935-9648
DOI: 10.1002/adma.201901513
Rights: This is the peer reviewed version of the following article: Yang, G., Phua, F. S. Z., Lim, W. Q., Zhang, R., Feng, L., Liu, G., ... Zhao, Y. (2019). A hypoxia-responsive albumin-based nanosystem for deep tumor penetration and excellent therapeutic efficacy. Advanced Materials, 31(25), 1901513-. doi:10.1002/adma.201901513, which has been published in final form at 10.1002/adma.201901513. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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