Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137696
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dc.contributor.authorWu, Luyanen_US
dc.contributor.authorSun, Yidanen_US
dc.contributor.authorSugimoto, Keisukeen_US
dc.contributor.authorLuo, Zhiliangen_US
dc.contributor.authorIshigaki, Yusukeen_US
dc.contributor.authorPu, Kanyien_US
dc.contributor.authorSuzuki, Takanorien_US
dc.contributor.authorChen, Hong-Yuanen_US
dc.contributor.authorYe, Dejuen_US
dc.date.accessioned2020-04-09T02:32:14Z-
dc.date.available2020-04-09T02:32:14Z-
dc.date.issued2018-
dc.identifier.citationWu, L., Sun, Y., Sugimoto, K., Luo, Z., Ishigaki, Y., Pu, K., . . . Ye, D. (2018). Engineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapy. Journal of the American Chemical Society, 140(47), 16340-16352. doi:10.1021/jacs.8b10176en_US
dc.identifier.issn0002-7863en_US
dc.identifier.urihttps://hdl.handle.net/10356/137696-
dc.description.abstractElectrochromic materials (EMs) are widely used color-switchable materials, but their applications as stimuli-responsive biomaterials to monitor and control biological processes remain unexplored. This study reports the engineering of an organic π-electron structure-based EM (dicationic 1,1,4,4-tetraarylbutadiene, 12+) as a unique hydrogen sulfide (H2S)-responsive chromophore amenable to build H2S-activatable fluorescent probes (12+-semiconducting polymer nanoparticles, 12+-SNPs) for in vivo H2S detection. We demonstrate that EM 12+, with a strong absorption (500–850 nm), efficiently quenches the fluorescence (580, 700, or 830 nm) of different fluorophores within 12+-SNPs, while the selective conversion into colorless diene 2 via H2S-mediated two-electron reduction significantly recovers fluorescence, allowing for non-invasive imaging of hepatic and tumor H2S in mice in real time. Strikingly, EM 12+ is further applied to design a near-infrared photosensitizer with tumor-targeting and H2S-activatable ability for effective photodynamic therapy (PDT) of H2S-related tumors in mice. This study demonstrates promise for applying EMs to build activatable probes for molecular imaging of H2S and selective PDT of tumors, which may lead to the development of new EMs capable of detecting and regulating essential biological processes in vivo.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of the American Chemical Societyen_US
dc.rights© 2018 American Chemical Society. All rights reserved.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleEngineering of electrochromic materials as activatable probes for molecular imaging and photodynamic therapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1021/jacs.8b10176-
dc.identifier.pmid30384600-
dc.identifier.scopus2-s2.0-85056714292-
dc.identifier.issue47en_US
dc.identifier.volume140en_US
dc.identifier.spage16340en_US
dc.identifier.epage16352en_US
dc.subject.keywordsAnatomyen_US
dc.subject.keywordsFluorescenceen_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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