Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137756
Title: Carbene-catalyzed direct functionalization of the β-sp3 -carbon atoms of α-chloroaldehydes
Authors: Liu, Bin
Luo, Guoyong
Wang, Hongling
Hao, Lin
Yang, Song
Jin, Zhichao
Chi, Robin Yonggui
Keywords: Science::Chemistry::Organic chemistry
Issue Date: 2019
Source: Liu, B., Luo, G., Wang, H., Hao, L., Yang, S., Jin, Z., & Chi, R. Y. (2019). Carbene-catalyzed direct functionalization of the β-sp3 -carbon atoms of α-chloroaldehydes. Chemistry – A European Journal, 25(55), 12719-12723. doi:10.1002/chem.201903592
Journal: Chemistry – A European Journal
Abstract: A direct functionalization of the β-sp3 carbon atom of α-chloro aldehyde has been developed. The reaction starts with the addition of a carbene catalyst to α-chloroaldehyde to eventually form the homoenolate intermediate. This overall redox-neutral process successfully converts the otherwise inert β-sp3 -carbon atom of the aldehyde substrate to a nucleophilic carbon atom for asymmetric reactions. This study constitutes the first success in activating α-chloroaldehydes to generate homoenolate intermediates by carbene organic catalysis and shall encourage further explorations in using organic catalysis for transforming inert chemical bonds.
URI: https://hdl.handle.net/10356/137756
ISSN: 0947-6539
DOI: 10.1002/chem.201903592
Rights: This is the peer reviewed version of the following article: Liu, B., Luo, G., Wang, H., Hao, L., Yang, S., Jin, Z., & Chi, R. Y. (2019). Carbene-catalyzed direct functionalization of the β-sp3 -carbon atoms of α-chloroaldehydes. Chemistry – A European Journal, 25(55), 12719-12723, which has been published in final form at https://doi.org/10.1002/chem.201903592. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: embargo_20201008
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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