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Title: Chiral nitroarenes as enantioselective single-electron-transfer oxidants for carbene-catalyzed radical reactions
Authors: Wang, Hongling
Wang, Yuhuang
Chen, Xingkuan
Mou, Chengli
Yu, Shuyan
Chai, Huifang
Jin, Zhichao
Chi, Robin Yonggui
Keywords: Science::Chemistry::Organic chemistry
Issue Date: 2019
Source: Wang, H., Wang, Y., Chen, X., Mou, C., Yu, S., Chai, H., ... , Chi, R. Y. (2019). Chiral nitroarenes as enantioselective single-electron-transfer oxidants for carbene-catalyzed radical reactions. Organic Letters, 21(18), 7440-7444. doi:10.1021/acs.orglett.9b02736
Journal: Organic Letters
Abstract: A new class of chiral oxidants is developed. These readily accessible oxidants contain a nitro group for oxidation and a chiral sulfonamide moiety for stereoselectivity control. The chiral information from the oxidants can effectively transfer to the substrates in carbene-catalyzed β-hydroxylation of enals via single-electron-transfer radical processes. We expect these oxidants to find unique applications in other asymmetric oxidations and oxygen-atom-transferring reactions.
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.9b02736
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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