Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137783
Title: Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan
Authors: Sun, Lijuan
Camps, Stefan G.
Goh, Hui Jen
Govindharajulu, Priya
Schaefferkoetter, Joshua D.
Townsend, David W.
Verma, Sanjay K.
Velan, S. Sendhil
Sun, Lei
Sze, Siu Kwan
Lim, Su Chi
Boehm, Bernhard Otto
Henry, Christiani Jeyakumar
Leow, Melvin Khee-Shing
Keywords: Science::Biological sciences
Issue Date: 2018
Source: Sun, L., Camps, S. G., Goh, H. J., Govindharajulu, P., Schaefferkoetter, J. D., Townsend, D. W., . . . Leow, M. K.-S. (2018). Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan. The American Journal of Clinical Nutrition, 107(1), 62-70. doi:10.1093/ajcn/nqx025
Journal: The American Journal of Clinical Nutrition
Abstract: Background: Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sought to prove that capsinoid-induced BAT activation can be visualized by 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). Objective: We compared capsinoids and cold exposure on BAT activation and whole-body EE. Design: Twenty healthy participants (8 men, 12 women) with a mean age of 26 y (range: 21–35 y) and a body mass index (kg/m2) of 21.7 (range: 18.5–26.0) underwent 18F-FDG PET and whole-body calorimetry after ingestion of 12 mg capsinoids or ≤2 h of cold exposure (∼14.5°C) in a crossover design. Mean standardized uptake values (SUVs) of the region of interest and BAT volumes were calculated. Blood metabolites were measured before and 2 h after each treatment. Results: All of the participants showed negligible 18F-FDG uptake post-capsinoid ingestion. Upon cold exposure, 12 participants showed avid 18F-FDG uptake into supraclavicular and lateral neck adipose tissues (BAT-positive group), whereas the remaining 8 participants (BAT-negative group) showed undetectable uptake. Capsinoids and cold exposure increased EE, although cold induced a 2-fold increase in whole-body EE and higher fat oxidation, insulin sensitivity, and HDL cholesterol compared with capsinoids. Conclusions: Capsinoids only increased EE in BAT-positive participants, which suggests that BAT mediates EE evoked by capsinoids. This implies that capsinoids stimulate BAT to a lesser degree than cold exposure as evidenced by 18F-FDG uptake below the presently accepted SUV thresholds defining BAT activation. This trial was registered at www.clinicaltrials.gov as NCT02964442.
URI: https://hdl.handle.net/10356/137783
ISSN: 0002-9165
DOI: 10.1093/ajcn/nqx025
Rights: © 2018 American Society for Nutrition (published by Oxford University Press). All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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