Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137826
Title: NaOH-promoted chemoselective cascade cyclization of cyclopropyl esters with unsaturated imines : access to bioactive cyclopenta[c]pyridine derivatives
Authors: Pan, Dingwu
Mou, Chengli
Zan, Ningning
Lv, Ya
Song, Bao-An
Chi, Robin Yonggui
Jin, Zhichao
Keywords: Science::Chemistry::Organic chemistry
Issue Date: 2019
Source: Pan, D., Mou, C., Zan, N., Lv, Y., Song, B.-A., Chi, R. Y., & Jin, Z. (2019). NaOH-promoted chemoselective cascade cyclization of cyclopropyl esters with unsaturated imines : access to bioactive cyclopenta[c]pyridine derivatives. Organic Letters, 21(17), 6624-6627. doi:10.1021/acs.orglett.9b02088
Journal: Organic Letters
Abstract: A chemoselective cascade cycloaddition reaction is developed for green and efficient access to cyclopenta[c]pyridine derivatives. Simple and inexpensive NaOH is used as the sole catalyst for this process. The δ-carbon of cyclopropyl ester is activated as a nucleophilic carbon to initiate highly chemoselective cascade reactions. Cyclopenta[c]pyridines bearing various substituents are afforded in excellent yields. Preliminary studies on the bioactivities of the afforded products show promising antibacterial activities for potential applications in plant protections.
URI: https://hdl.handle.net/10356/137826
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.9b02088
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.9b02088
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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