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Title: Biomechano-interactive materials and interfaces
Authors: Cai, Pingqiang
Hu, Benhui
Leow, Wan Ru
Wang, Xiaoyuan
Loh, Xian Jun
Wu, Yun-Long
Chen, Xiaodong
Keywords: Engineering::Materials
Issue Date: 2018
Source: Cai, P., Hu, B., Leow, W. R., Wang, X., Loh, X. J., Wu, Y.-L., & Chen, X. D. (2018). Biomechano-interactive materials and interfaces. Advanced materials, 30(31), 1800572-. doi:10.1002/adma.201800572
Journal: Advanced materials
Abstract: The reciprocal mechanical interaction of engineered materials with biointerfaces have long been observed and exploited in biomedical applications. It contributes to the rise of biomechano-responsive materials and biomechano-stimulatory materials, constituting the biomechano-interactive interfaces. Here, endogenous and exogenous biomechanical stimuli available for mechanoresponsive interfaces are briefed and their mechanistic responses, including deformation and volume change, mechanomanipulation of physical and chemical bonds, dissociation of assemblies, and coupling with thermoresponsiveness are summarized. The mechanostimulatory materials, however, are capable of delivering mechanical cues, including stiffness, viscoelasticity, geometrical constraints, and mechanical loads, to modulate physiological and pathological behaviors of living tissues through the adaptive cellular mechanotransduction. The biomechano-interactive materials and interfaces are widely implemented in such fields as mechanotriggered therapeutics and diagnosis, adaptive biophysical sensors, biointegrated soft actuators, and mechanorobust tissue engineering, which have offered unprecedented opportunities for precision and personalized medicine. Pending challenges are also addressed to shed a light on future advances with respect to translational implementations.
ISSN: 0935-9648
DOI: 10.1002/adma.201800572
Rights: © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. This paper was published in Advanced materials and is made available with permission of WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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