Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137900
Title: Enantio- and diastereoselective synthesis of chromeno[4,3-b]pyrrole derivatives bearing tetrasubstituted chirality centers through carbene catalyzed cascade reactions
Authors: Li, Tingting
Wang, Jilan
Xu, Jun
Jin, Jiamiao
Chi, Robin Yonggui
Jin, Zhichao
Keywords: Science::Chemistry::Organic chemistry
Issue Date: 2019
Source: Li, T., Wang, J., Xu, J., Jin, J., Chi, R. Y., & Jin, Z. (2020). Enantio- and diastereoselective synthesis of chromeno[4,3-b]pyrrole derivatives bearing tetrasubstituted chirality centers through carbene catalyzed cascade reactions. Organic Letters, 22(1), 326-330. doi:10.1021/acs.orglett.9b04371
Journal: Organic Letters
Abstract: An NHC-catalyzed cascade cycloaddition reaction is developed for quick access to structurally sophisticated tetrahydrochromeno[4,3-b]pyrrole derivatives. A sterically congested tetrasubstituted chirality carbon center is formed during the cyclization process. All the α-, β-, and carbonyl carbons of the enal substrates are functionalized in chemo- and stereoselective fashion. The multicyclic chromeno[4,3-b]pyrrole products are generally afforded in good yields with excellent enantio- and diastereoselectivities. Heavily substituted pyrroline derivatives can be afforded from the chiral products through simple protocols.
URI: https://hdl.handle.net/10356/137900
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.9b04371
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.9b04371
Fulltext Permission: embargo_20210110
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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  Until 2021-01-10
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