Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/137927
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dc.contributor.authorWu, Xingxingen_US
dc.contributor.authorZhou, Liejinen_US
dc.contributor.authorMaiti, Rakeshen_US
dc.contributor.authorMou, Chenglien_US
dc.contributor.authorPan, Lutaien_US
dc.contributor.authorChi, Robin Yongguien_US
dc.date.accessioned2020-04-20T00:51:12Z-
dc.date.available2020-04-20T00:51:12Z-
dc.date.issued2018-
dc.identifier.citationWu, X., Zhou, L., Maiti, R., Mou, C., Pan, L., & Chi, R. Y. (2019). Sulfinate and carbene co-catalyzed Rauhut-Currier reaction for enantioselective access to azepino[1,2-a]indoles. Angewandte Chemie International Edition, 58(2), 477-481. doi:10.1002/anie.201810879en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttps://hdl.handle.net/10356/137927-
dc.description.abstractA carbene and sulfinate co-catalyzed intermolecular Rauhut-Currier reaction between enals and nitrovinyl indoles is disclosed. The carbene catalyst activates the enal and the sulfinate co-catalyst activates the nitrovinyl indole. Both activation processes are realized via the formation of covalent bonds between the catalysts and substrates to generate catalyst-bound intermediates. The dual catalytic reaction affords azepino[1,2-a]indole products with excellent stereoselectivity. Our study demonstrates the unique involvement of sulfinate as an effective nucleophilic catalyst in activating electron-deficient alkenes for asymmetric reactions. This dual catalytic approach should also encourage future explorations of both sulfinate and carbene catalysts for new reactions.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofAngewandte Chemie International Editionen_US
dc.rightsThis is the peer reviewed version of the following article: Wu, X., Zhou, L., Maiti, R., Mou, C., Pan, L., & Chi, R. Y. (2019). Sulfinate and carbene co-catalyzed Rauhut-Currier reaction for enantioselective access to azepino[1,2-a]indoles. Angewandte Chemie International Edition, 58(2), 477-481, which has been published in final form at https://doi.org/10.1002/anie.201810879. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.subjectScience::Chemistry::Organic chemistryen_US
dc.titleSulfinate and carbene co-catalyzed Rauhut-Currier reaction for enantioselective access to azepino[1,2-a]indolesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1002/anie.201810879-
dc.description.versionAccepted versionen_US
dc.identifier.pmid30398684-
dc.identifier.scopus2-s2.0-85058093336-
dc.identifier.issue2en_US
dc.identifier.volume58en_US
dc.identifier.spage477en_US
dc.identifier.epage481en_US
dc.subject.keywordsCooperative Catalysisen_US
dc.subject.keywordsIndolesen_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
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