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|Title:||Kinetic resolution of 1,2-diols via NHC-catalyzed site-selective esterification||Authors:||Liu, Bin
Chi, Robin Yonggui
|Keywords:||Science::Chemistry::Organic chemistry||Issue Date:||2018||Source:||Liu, B., Yan, K., Huang, R., Wang, W., Jin, Z, Zanoni, G., . . ., Chi, R. Y. (2018). Kinetic resolution of 1,2-diols via NHC-catalyzed site-selective esterification. Organic letters, 20(12), 3447-3450. doi:10.1021/acs.orglett.8b01029||Journal:||Organic letters||Abstract:||A kinetic resolution of 1,2-diols bearing both a secondary and a primary alcohol motif through an N-heterocyclic carbene-catalyzed oxidative acylation reaction has been developed. A site- and enantioselective esterification reaction is involved for this process. Both the monoacylated diols obtained and the remaining enantioenriched 1,2-diols are versatile building blocks for the preparation of functional molecules with proven biological activities.||URI:||https://hdl.handle.net/10356/138240||ISSN:||1523-7052||DOI:||10.1021/acs.orglett.8b01029||Rights:||© 2018 American Chemical Society. All rights reserved. This paper was published in Organic letters and is made available with permission of American Chemical Society.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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