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Title: Kinetic resolution of 1,2-diols via NHC-catalyzed site-selective esterification
Authors: Liu, Bin
Yan, Jiekuan
Huang, Ruoyan
Wang, Weihong
Jin, Zhichao
Zanoni, Giuseppe
Zheng, Pengcheng
Yang, Song
Chi, Robin Yonggui
Keywords: Science::Chemistry::Organic chemistry
Issue Date: 2018
Source: Liu, B., Yan, K., Huang, R., Wang, W., Jin, Z, Zanoni, G., . . ., Chi, R. Y. (2018). Kinetic resolution of 1,2-diols via NHC-catalyzed site-selective esterification. Organic letters, 20(12), 3447-3450. doi:10.1021/acs.orglett.8b01029
Journal: Organic letters
Abstract: A kinetic resolution of 1,2-diols bearing both a secondary and a primary alcohol motif through an N-heterocyclic carbene-catalyzed oxidative acylation reaction has been developed. A site- and enantioselective esterification reaction is involved for this process. Both the monoacylated diols obtained and the remaining enantioenriched 1,2-diols are versatile building blocks for the preparation of functional molecules with proven biological activities.
ISSN: 1523-7052
DOI: 10.1021/acs.orglett.8b01029
Schools: School of Physical and Mathematical Sciences 
Rights: © 2018 American Chemical Society. All rights reserved. This paper was published in Organic letters and is made available with permission of American Chemical Society.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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