Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/138257
Title: Direct activation of β-sp3-carbons of saturated carboxylic esters as electrophilic carbons via oxidative carbene catalysis
Authors: Liu, Bin
Wang, Weihong
Huang, Ruoyan
Yan, Jiekuan
Wu, Jichang
Xue, Wei
Yang, Song
Jin, Zhichao
Chi, Robin Yonggui
Keywords: Science::Chemistry::Organic chemistry
Issue Date: 2018
Source: Liu, B., Wang, W., Huang, R., Yan, J., Wu, J., Xue, W., . . ., Chi, R. Y. (2018). Direct activation of β-sp3-carbons of saturated carboxylic esters as electrophilic carbons via oxidative carbene catalysis. Organic letters, 20(1), 260-263. doi:10.1021/acs.orglett.7b03650
Journal: Organic letters
Abstract: An N-heterocyclic carbene-catalyzed oxidative LUMO activation of the β-cabons of saturated carboxylic esters is disclosed. This approach allows for efficient asymmetric access to lactams and lactones by directly installing functional groups to the typically inert β-sp3 carbons of saturated esters. The use of HOBt as an additive was found to significantly improve both yields and enantioselectivities of the reactions.
URI: https://hdl.handle.net/10356/138257
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.7b03650
Rights: © 2017 American Chemical Society. All rights reserved. This paper was published in Organic letters and is made available with permission of American Chemical Society.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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