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|Title:||Direct activation of β-sp3-carbons of saturated carboxylic esters as electrophilic carbons via oxidative carbene catalysis||Authors:||Liu, Bin
Chi, Robin Yonggui
|Keywords:||Science::Chemistry::Organic chemistry||Issue Date:||2018||Source:||Liu, B., Wang, W., Huang, R., Yan, J., Wu, J., Xue, W., . . ., Chi, R. Y. (2018). Direct activation of β-sp3-carbons of saturated carboxylic esters as electrophilic carbons via oxidative carbene catalysis. Organic letters, 20(1), 260-263. doi:10.1021/acs.orglett.7b03650||Journal:||Organic letters||Abstract:||An N-heterocyclic carbene-catalyzed oxidative LUMO activation of the β-cabons of saturated carboxylic esters is disclosed. This approach allows for efficient asymmetric access to lactams and lactones by directly installing functional groups to the typically inert β-sp3 carbons of saturated esters. The use of HOBt as an additive was found to significantly improve both yields and enantioselectivities of the reactions.||URI:||https://hdl.handle.net/10356/138257||ISSN:||1523-7060||DOI:||10.1021/acs.orglett.7b03650||Rights:||© 2017 American Chemical Society. All rights reserved. This paper was published in Organic letters and is made available with permission of American Chemical Society.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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