Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/138257
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dc.contributor.authorLiu, Binen_US
dc.contributor.authorWang, Weihongen_US
dc.contributor.authorHuang, Ruoyanen_US
dc.contributor.authorYan, Jiekuanen_US
dc.contributor.authorWu, Jichangen_US
dc.contributor.authorXue, Weien_US
dc.contributor.authorYang, Songen_US
dc.contributor.authorJin, Zhichaoen_US
dc.contributor.authorChi, Robin Yongguien_US
dc.date.accessioned2020-04-30T00:50:35Z-
dc.date.available2020-04-30T00:50:35Z-
dc.date.issued2018-
dc.identifier.citationLiu, B., Wang, W., Huang, R., Yan, J., Wu, J., Xue, W., . . ., Chi, R. Y. (2018). Direct activation of β-sp3-carbons of saturated carboxylic esters as electrophilic carbons via oxidative carbene catalysis. Organic letters, 20(1), 260-263. doi:10.1021/acs.orglett.7b03650en_US
dc.identifier.issn1523-7060en_US
dc.identifier.urihttps://hdl.handle.net/10356/138257-
dc.description.abstractAn N-heterocyclic carbene-catalyzed oxidative LUMO activation of the β-cabons of saturated carboxylic esters is disclosed. This approach allows for efficient asymmetric access to lactams and lactones by directly installing functional groups to the typically inert β-sp3 carbons of saturated esters. The use of HOBt as an additive was found to significantly improve both yields and enantioselectivities of the reactions.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofOrganic lettersen_US
dc.rights© 2017 American Chemical Society. All rights reserved. This paper was published in Organic letters and is made available with permission of American Chemical Society.en_US
dc.subjectScience::Chemistry::Organic chemistryen_US
dc.titleDirect activation of β-sp3-carbons of saturated carboxylic esters as electrophilic carbons via oxidative carbene catalysisen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1021/acs.orglett.7b03650-
dc.description.versionAccepted versionen_US
dc.identifier.pmid29239615-
dc.identifier.scopus2-s2.0-85040246325-
dc.identifier.issue1en_US
dc.identifier.volume20en_US
dc.identifier.spage260en_US
dc.identifier.epage263en_US
dc.subject.keywordsNHC Catalysten_US
dc.subject.keywordsCarboxylic Estersen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
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