Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/138269
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dc.contributor.authorSun, Junen_US
dc.contributor.authorHe, Fangchengen_US
dc.contributor.authorWang, Zhongyaoen_US
dc.contributor.authorPan, Dingwuen_US
dc.contributor.authorZheng, Pengchengen_US
dc.contributor.authorMou, Chenglien_US
dc.contributor.authorJin, Zhichaoen_US
dc.contributor.authorChi, Robin Yongguien_US
dc.date.accessioned2020-04-30T01:58:49Z-
dc.date.available2020-04-30T01:58:49Z-
dc.date.issued2018-
dc.identifier.citationSun, J., He, F., Wang, Z., Pan, D., Zheng, P., Mou, C., . . ., Chi, R. Y. (2018). Carbene-catalyzed enal γ-carbon addition to α-ketophosphonates for enantioselective access to bioactive 2-pyranylphosphonates. Chemical Communications, 54(47), 6040-6043. doi:10.1039/C8CC03017Ken_US
dc.identifier.issn1359-7345en_US
dc.identifier.urihttps://hdl.handle.net/10356/138269-
dc.description.abstractA carbene-catalyzed enantioselective [4+2] cycloaddition reaction between a,b-unsaturated aldehydes and a-ketophosphonates is developed. The reaction affords chiral 2-pyranylphosphonates with excellent enantioselectivities. The optically enriched phosphonate products bear multiple functional groups, including unsaturated lactone and phosphonate moieties that often lead to unique bio-activities. Preliminary studies show that the products from our reactions exhibit anti-bacterial (X. oryzae pv. oryzae) and anti-viral (Tobacco Mosaic Virus) activities for potential use in plant protection.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofChemical Communicationsen_US
dc.rights© 2018 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry.en_US
dc.subjectScience::Chemistry::Organic chemistryen_US
dc.titleCarbene-catalyzed enal γ-carbon addition to α-ketophosphonates for enantioselective access to bioactive 2-pyranylphosphonatesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.identifier.doi10.1039/C8CC03017K-
dc.description.versionAccepted versionen_US
dc.identifier.issue47en_US
dc.identifier.volume54en_US
dc.identifier.spage6040en_US
dc.identifier.epage6043en_US
dc.subject.keywordsNHC Catalysten_US
dc.subject.keywordsEnantioselectivitiesen_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
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