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Title: Visible-light photoredox enables ketone carbonyl alkylation for easy access to tertiary alcohols
Authors: Vu, Minh Duy
Das, Mrinmoy
Guo, Aoxin
Ang, Zi-En
D̵okić, Miloš
Soo, Han Sen
Liu, Xue-Wei
Keywords: Science::Chemistry::Organic chemistry
Issue Date: 2019
Source: Vu, M. D., Das, M., Guo, A., Ang, Z.-E., D̵okić, M., Soo, H. S., & Liu, X.-W. (2019). Visible-light photoredox enables ketone carbonyl alkylation for easy access to tertiary alcohols. ACS Catalysis, 9(10), 9009-9014. doi:10.1021/acscatal.9b02401
Journal: ACS Catalysis
Abstract: Being a handle for synthesizing quaternary carbon centers and olefins, together with ubiquitous appearance in organic building blocks, makes tertiary alcohols valuable targets in synthesis. However, traditional syntheses of these alcohols have faced several challenges including the employment of functionalized reactive reagents, undesirable side reactions, and decomposition of the alcohol products under harsh conditions. The paucity of a synthetic approach to bulky tertiary alcohols prompts our interest to develop a benign catalytic protocol to tackle the current issues. Here, we have successfully demonstrated the use of ketyl radicals in intermolecular cross radical-radical coupling, which has opened a different door for accessing complex tertiary alcohols. On the other hand, by starting from feedstock and naturally derived chemicals without any pre-activation, it would be superior to traditional methodologies in the industrial context.
ISSN: 2155-5435
DOI: 10.1021/acscatal.9b02401
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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