Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/138815
Title: Glycosylated copper sulfide nanocrystals for targeted photokilling of bacteria in the near‐infrared II window
Authors: Hou, Shuai
Mahadevegowda, Surendra Hittanahalli
Mai, Van Cuong
Chan‐Park, Mary Bee Eng
Duan, Hongwei
Keywords: Engineering::Chemical engineering
Issue Date: 2019
Source: Hou, S., Mahadevegowda, S. H., Mai, V. C., Chan‐Park, M. B., & Duan, H. (2019). Glycosylated copper sulfide nanocrystals for targeted photokilling of bacteria in the near‐infrared II window. Advanced Therapeutics, 2(8), 1900052-. doi:10.1002/adtp.201900052
Journal: Advanced Therapeutics
Abstract: Photothermal and photodynamic therapies are established as alternative approaches to combating bacterial infections; however, the heat and reactive oxygen species generated by the photoagents act on both normal and bacterial cells. A targeting strategy is thus required to minimize side effects and enhance the antibacterial efficiency. Glycoconjugates specifically interacting with bacterial lectins have emerged as a new class of materials for targeting bacteria. In this paper, galactosylated plasmonic copper sulfide nanocrystals (Cu2−xS NCs) are used to target Pseudomonas aeruginosa via galactose–LecA interactions and kill the bacteria by simultaneous photothermal and photodynamic therapy. Galactosylated Cu2−xS NCs are obtained by functionalizing the nanocrystals with tri‐thiogalactoside glycoclusters. The excellent specificity of galactosylated nanoparticles toward LecA with a LecA‐deficient P. aeruginosa strain as the control is first demonstrated. Afterward, a laser in the near‐infrared II window is used to kill the bacteria, and the critical role of targeted binding in efficient killing of bacteria is highlighted. This approach can be readily generalized to the targeting of other pathogens which have highly specific carbohydrate‐binding lectins.
URI: https://hdl.handle.net/10356/138815
ISSN: 2366-3987
DOI: 10.1002/adtp.201900052
Rights: This is the peer reviewed version of the following article: Hou, S., Mahadevegowda, S. H., Mai, V. C., Chan‐Park, M. B., & Duan, H. (2019). Glycosylated copper sulfide nanocrystals for targeted photokilling of bacteria in the near‐infrared II window. Advanced Therapeutics, 2(8), 1900052-. doi:10.1002/adtp.201900052, which has been published in final form at :10.1002/adtp.201900052. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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