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Title: Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide
Authors: Jackman, Joshua A.
Costa, Vivian V.
Park, Soohyun
Real, Ana Luiza Campos Vila
Park, Jae Hyeon
Cardozo, Pablo L.
Abdul Rahim Ferhan
Olmo, Isabella G.
Moreira, Thaiane P.
Bambirra, Jordana L.
Queiroz, Victoria F.
Queiroz-Junior, Celso M.
Foureaux, Giselle
Souza, Danielle G.
Ribeiro, Fabiola M.
Yoon, Bo Kyeong
Wynendaele, Evelien
Spiegeleer, Bart De
Teixeira, Mauro M.
Cho, Nam-Joon
Keywords: Science::Medicine
Issue Date: 2018
Source: Jackman, J. A., Costa, V. V., Park, S., Real, A. L. C. V., Park, J. H., Cardozo, P. L., . . . Cho, N.-J. (2018). Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide. Nature Materials, 17(11), 971-977. doi:10.1038/s41563-018-0194-2
Journal: Nature Materials
Abstract: Zika virus is a mosquito-borne virus that is associated with neurodegenerative diseases, including Guillain-Barré syndrome1 and congenital Zika syndrome2. As Zika virus targets the nervous system, there is an urgent need to develop therapeutic strategies that inhibit Zika virus infection in the brain. Here, we have engineered a brain-penetrating peptide that works against Zika virus and other mosquito-borne viruses. We evaluated the therapeutic efficacy of the peptide in a lethal Zika virus mouse model exhibiting systemic and brain infection. Therapeutic treatment protected against mortality and markedly reduced clinical symptoms, viral loads and neuroinflammation, as well as mitigated microgliosis, neurodegeneration and brain damage. In addition to controlling systemic infection, the peptide crossed the blood-brain barrier to reduce viral loads in the brain and protected against Zika-virus-induced blood-brain barrier injury. Our findings demonstrate how engineering strategies can be applied to develop peptide therapeutics and support the potential of a brain-penetrating peptide to treat neurotropic viral infections.
ISSN: 1476-1122
DOI: 10.1038/s41563-018-0194-2
Rights: © 2018 The Author(s), under exclusive licence to Springer Nature Limited. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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