| Title: | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits |
Authors: | Evangelou, Evangelos
Warren, Helen R.
Mosen-Ansorena, David
Mifsud, Borbala
Pazoki, Raha
Gao, He
Ntritsos, Georgios
Dimou, Niki
Cabrera, Claudia P.
Ibrahim Karaman
Ng, Fu Liang
Evangelou, Marina
Witkowska, Katarzyna
Tzanis, Evan
Hellwege, Jacklyn N.
Giri, Ayush
Edwards, Digna R. Velez
Sun, Yan V.
Cho, Kelly
Gaziano, J. Michael
Wilson, Peter W. F.
Tsao, Philip S.
Kovesdy, Csaba P.
Esko, Tonu
Mägi, Reedik
Milani, Lili
Almgren, Peter
Boutin, Thibaud
Debette, Stéphanie
Ding, Jun
Giulianini, Franco
Holliday, Elizabeth G.
Jackson, Anne U.
Li-Gao, Ruifang
Lin, Wei-Yu
Luan, Jian'an
Mangino, Massimo
Oldmeadow, Christopher
Prins, Bram Peter
Qian, Yong
Sargurupremraj, Muralidharan
Shah, Nabi
Surendran, Praveen
Thériault, Sébastien
Verweij, Niek
Willems, Sara M.
Zhao, Jing-Hua
Amouyel, Philippe
Connell, John
de Mutsert, Renée
Doney, Alex S. F.
Farrall, Martin
Menni, Cristina
Morris, Andrew D.
Raymond Noordam
Paré, Guillaume
Poulter, Neil R.
Shields, Denis C.
Stanton, Alice
Thom, Simon
Abecasis, Gonçalo
Najaf Amin
Arking, Dan E.
Ayers, Kristin L.
Barbieri, Caterina M.
Batini, Chiara
Bis, Joshua C. M.
Blake, Tineka
Bochud, Murielle
Boehnke, Michael
Boerwinkle, Eric
Boomsma, Dorret I.
Bottinger, Erwin P.
Braund, Peter S.
Brumat, Marco
Campbell, Archie
Campbell, Harry
Chakravarti, Aravinda
Chambers, John Campbell
Chauhan, Ganesh
Ciullo, Marina
Cocca, Massimiliano
Collins, Francis
Cordell, Heather J.
Davies, Gail
de Borst, Martin H.
de Geus, Eco J.
Deary, Ian J.
Deelen, Joris
Del Greco M., Fabiola
Demirkale, Cumhur Yusuf
Dörr, Marcus
Ehret, Georg B.
Elosua, Roberto
Enroth, Stefan
Erzurumluoglu, A. Mesut
Ferreira, Teresa
Frånberg, Mattias
Franco, Oscar H.
Gandin, Ilaria
Gasparini, Paolo
Giedraitis, Vilmantas
Gieger, Christian
Girotto, Giorgia
Goel, Anuj
Gow, Alan J.
Gudnason, Vilmundur
Guo, Xiuqing
Gyllensten, Ulf
Hamsten, Anders
Harris, Tamara B.
Harris, Sarah E.
Hartman, Catharina A.
Havulinna, Aki S.
Hicks, Andrew A.
Hofer, Edith
Hofman, Albert
Hottenga, Jouke-Jan
Huffman, Jennifer E.
Hwang, Shih-Jen
Ingelsson, Erik
James, Alan
Jansen, Rick
Jarvelin, Marjo-Riitta
Joehanes, Roby
Johansson, Åsa
Johnson, Andrew D.
Joshi, Peter K.
Jousilahti, Pekka
Jukema, J. Wouter
Jula, Antti
Kähönen, Mika
Kathiresan, Sekar
Keavney, Bernard D.
Khaw, Kay-Tee
Knekt, Paul
Knight, Joanne
Kolcic, Ivana
Kooner, Jaspal S.
Koskinen, Seppo
Kristiansson, Kati
Kutalik, Zoltan
Laan, Maris
Larson, Marty
Launer, Lenore J.
Lehne, Benjamin
Lehtimäki, Terho
Liewald, David C. M.
Lin, Li
Lind, Lars
Lindgren, Cecilia M.
Liu, YongMei
Loos, Ruth J. F.
Lopez, Lorna M.
Lu, Yingchang
Lyytikäinen, Leo-Pekka
Mahajan, Anubha
Mamasoula, Chrysovalanto
Marrugat, Jaume
Marten, Jonathan
Milaneschi, Yuri
Morgan, Anna
Morris, Andrew P.
Morrison, Alanna C.
Munson, Peter J.
Nalls, Mike A.
Nandakumar, Priyanka
Nelson, Christopher P.
Niiranen, Teemu
Nolte, Ilja M.
Nutile, Teresa
Oldehinkel, Albertine J.
Oostra, Ben A.
O'Reilly, Paul F.
Org, Elin
Padmanabhan, Sandosh
Palmas, Walter
Palotie, Aarno
Pattie, Alison
Penninx, Brenda W. J. H.
Perola, Markus
Peters, Annette
Polasek, Ozren
Pramstaller, Peter P.
Nguyen, Quang Tri
Raitakari, Olli T.
Ren, Meixia
Rettig, Rainer
Rice, Kenneth
Ridker, Paul M.
Ried, Janina S.
Riese, Harriëtte
Ripatti, Samuli
Robino, Antonietta
Rose, Lynda M.
Rotter, Jerome I.
Rudan, Igor
Ruggiero, Daniela
Saba, Yasaman
Sala, Cinzia F.
Salomaa, Veikko
Samani, Nilesh J.
Sarin, Antti-Pekka
Schmidt, Reinhold
Schmidt, Helena
Shrine, Nick
Siscovick, David
Smith, Albert V.
Snieder, Harold
Sõber, Siim
Sorice, Rossella
Starr, John M.
Stott, David J.
Strachan, David P.
Strawbridge, Rona J.
Sundström, Johan
Swertz, Morris A.
Taylor, Kent D.
Teumer, Alexander
Tobin, Martin D.
Tomaszewski, Maciej
Toniolo, Daniela
Traglia, Michela
Trompet, Stella
Tuomilehto, Jaakko
Tzourio, Christophe
Uitterlinden, André G.
Vaez, Ahmad
van der Most, Peter J.
van Duijn, Cornelia M.
Vergnaud, Anne-Claire
Verwoert, Germaine C.
Vitart, Veronique
Völker, Uwe
Vollenweider, Peter
Vuckovic, Dragana
Watkins, Hugh
Wild, Sarah H.
Willemsen, Gonneke
Wilson, James F.
Wright, Alan F.
Yao, Jie
Zemunik, Tatijana
Zhang, Weihua
Attia, John R.
Butterworth, Adam S.
Chasman, Daniel I.
Conen, David
Cucca, Francesco
Danesh, John
Hayward, Caroline
Howson, Joanna M. M.
Laakso, Markku
Lakatta, Edward G.
Langenberg, Claudia
Melander, Olle
Mook-Kanamori, Dennis O.
Palmer, Colin N. A.
Risch, Lorenz
Scott, Robert A.
Scott, Rodney J.
Sever, Peter
Spector, Tim D.
van der Harst, Pim
Wareham, Nicholas J.
Zeggini, Eleftheria
Levy, Daniel
Munroe, Patricia B.
Newton-Cheh, Christopher
Brown, Morris J.
Metspalu, Andres
Hung, Adriana M.
O'Donnell, Christopher J.
Edwards, Todd L.
Psaty, Bruce M.
Tzoulaki, Ioanna
Barnes, Michael R.
Wain, Louise V.
Elliott, Paul
Caulfield, Mark J. |
Keywords: | Science::Medicine |
Issue Date: | 2018 |
Source: | Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., . . . Caulfield, M. J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50(10), 1412-1425. doi:10.1038/s41588-018-0205-x |
Journal: | Nature Genetics |
Abstract: | High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. |
URI: | https://hdl.handle.net/10356/138835 |
ISSN: | 1061-4036 |
DOI: | 10.1038/s41588-018-0205-x |
Schools: | Lee Kong Chian School of Medicine (LKCMedicine) |
Rights: | © 2018 The Author(s) (Nature Publishing Group). All rights reserved. |
Fulltext Permission: | none |
Fulltext Availability: | No Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles
|
