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dc.contributor.authorEvangelou, Evangelosen_US
dc.contributor.authorWarren, Helen R.en_US
dc.contributor.authorMosen-Ansorena, Daviden_US
dc.contributor.authorMifsud, Borbalaen_US
dc.contributor.authorPazoki, Rahaen_US
dc.contributor.authorGao, Heen_US
dc.contributor.authorNtritsos, Georgiosen_US
dc.contributor.authorDimou, Nikien_US
dc.contributor.authorCabrera, Claudia P.en_US
dc.contributor.authorIbrahim Karamanen_US
dc.contributor.authorNg, Fu Liangen_US
dc.contributor.authorEvangelou, Marinaen_US
dc.contributor.authorWitkowska, Katarzynaen_US
dc.contributor.authorTzanis, Evanen_US
dc.contributor.authorHellwege, Jacklyn N.en_US
dc.contributor.authorGiri, Ayushen_US
dc.contributor.authorEdwards, Digna R. Velezen_US
dc.contributor.authorSun, Yan V.en_US
dc.contributor.authorCho, Kellyen_US
dc.contributor.authorGaziano, J. Michaelen_US
dc.contributor.authorWilson, Peter W. F.en_US
dc.contributor.authorTsao, Philip S.en_US
dc.contributor.authorKovesdy, Csaba P.en_US
dc.contributor.authorEsko, Tonuen_US
dc.contributor.authorMägi, Reediken_US
dc.contributor.authorMilani, Lilien_US
dc.contributor.authorAlmgren, Peteren_US
dc.contributor.authorBoutin, Thibauden_US
dc.contributor.authorDebette, Stéphanieen_US
dc.contributor.authorDing, Junen_US
dc.contributor.authorGiulianini, Francoen_US
dc.contributor.authorHolliday, Elizabeth G.en_US
dc.contributor.authorJackson, Anne U.en_US
dc.contributor.authorLi-Gao, Ruifangen_US
dc.contributor.authorLin, Wei-Yuen_US
dc.contributor.authorLuan, Jian'anen_US
dc.contributor.authorMangino, Massimoen_US
dc.contributor.authorOldmeadow, Christopheren_US
dc.contributor.authorPrins, Bram Peteren_US
dc.contributor.authorQian, Yongen_US
dc.contributor.authorSargurupremraj, Muralidharanen_US
dc.contributor.authorShah, Nabien_US
dc.contributor.authorSurendran, Praveenen_US
dc.contributor.authorThériault, Sébastienen_US
dc.contributor.authorVerweij, Nieken_US
dc.contributor.authorWillems, Sara M.en_US
dc.contributor.authorZhao, Jing-Huaen_US
dc.contributor.authorAmouyel, Philippeen_US
dc.contributor.authorConnell, Johnen_US
dc.contributor.authorde Mutsert, Renéeen_US
dc.contributor.authorDoney, Alex S. F.en_US
dc.contributor.authorFarrall, Martinen_US
dc.contributor.authorMenni, Cristinaen_US
dc.contributor.authorMorris, Andrew D.en_US
dc.contributor.authorRaymond Noordamen_US
dc.contributor.authorParé, Guillaumeen_US
dc.contributor.authorPoulter, Neil R.en_US
dc.contributor.authorShields, Denis C.en_US
dc.contributor.authorStanton, Aliceen_US
dc.contributor.authorThom, Simonen_US
dc.contributor.authorAbecasis, Gonçaloen_US
dc.contributor.authorNajaf Aminen_US
dc.contributor.authorArking, Dan E.en_US
dc.contributor.authorAyers, Kristin L.en_US
dc.contributor.authorBarbieri, Caterina M.en_US
dc.contributor.authorBatini, Chiaraen_US
dc.contributor.authorBis, Joshua C. M.en_US
dc.contributor.authorBlake, Tinekaen_US
dc.contributor.authorBochud, Murielleen_US
dc.contributor.authorBoehnke, Michaelen_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorBoomsma, Dorret I.en_US
dc.contributor.authorBottinger, Erwin P.en_US
dc.contributor.authorBraund, Peter S.en_US
dc.contributor.authorBrumat, Marcoen_US
dc.contributor.authorCampbell, Archieen_US
dc.contributor.authorCampbell, Harryen_US
dc.contributor.authorChakravarti, Aravindaen_US
dc.contributor.authorChambers, John Campbellen_US
dc.contributor.authorChauhan, Ganeshen_US
dc.contributor.authorCiullo, Marinaen_US
dc.contributor.authorCocca, Massimilianoen_US
dc.contributor.authorCollins, Francisen_US
dc.contributor.authorCordell, Heather J.en_US
dc.contributor.authorDavies, Gailen_US
dc.contributor.authorde Borst, Martin H.en_US
dc.contributor.authorde Geus, Eco J.en_US
dc.contributor.authorDeary, Ian J.en_US
dc.contributor.authorDeelen, Jorisen_US
dc.contributor.authorDel Greco M., Fabiolaen_US
dc.contributor.authorDemirkale, Cumhur Yusufen_US
dc.contributor.authorDörr, Marcusen_US
dc.contributor.authorEhret, Georg B.en_US
dc.contributor.authorElosua, Robertoen_US
dc.contributor.authorEnroth, Stefanen_US
dc.contributor.authorErzurumluoglu, A. Mesuten_US
dc.contributor.authorFerreira, Teresaen_US
dc.contributor.authorFrånberg, Mattiasen_US
dc.contributor.authorFranco, Oscar H.en_US
dc.contributor.authorGandin, Ilariaen_US
dc.contributor.authorGasparini, Paoloen_US
dc.contributor.authorGiedraitis, Vilmantasen_US
dc.contributor.authorGieger, Christianen_US
dc.contributor.authorGirotto, Giorgiaen_US
dc.contributor.authorGoel, Anujen_US
dc.contributor.authorGow, Alan J.en_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorGuo, Xiuqingen_US
dc.contributor.authorGyllensten, Ulfen_US
dc.contributor.authorHamsten, Andersen_US
dc.contributor.authorHarris, Tamara B.en_US
dc.contributor.authorHarris, Sarah E.en_US
dc.contributor.authorHartman, Catharina A.en_US
dc.contributor.authorHavulinna, Aki S.en_US
dc.contributor.authorHicks, Andrew A.en_US
dc.contributor.authorHofer, Edithen_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorHottenga, Jouke-Janen_US
dc.contributor.authorHuffman, Jennifer E.en_US
dc.contributor.authorHwang, Shih-Jenen_US
dc.contributor.authorIngelsson, Eriken_US
dc.contributor.authorJames, Alanen_US
dc.contributor.authorJansen, Ricken_US
dc.contributor.authorJarvelin, Marjo-Riittaen_US
dc.contributor.authorJoehanes, Robyen_US
dc.contributor.authorJohansson, Åsaen_US
dc.contributor.authorJohnson, Andrew D.en_US
dc.contributor.authorJoshi, Peter K.en_US
dc.contributor.authorJousilahti, Pekkaen_US
dc.contributor.authorJukema, J. Wouteren_US
dc.contributor.authorJula, Anttien_US
dc.contributor.authorKähönen, Mikaen_US
dc.contributor.authorKathiresan, Sekaren_US
dc.contributor.authorKeavney, Bernard D.en_US
dc.contributor.authorKhaw, Kay-Teeen_US
dc.contributor.authorKnekt, Paulen_US
dc.contributor.authorKnight, Joanneen_US
dc.contributor.authorKolcic, Ivanaen_US
dc.contributor.authorKooner, Jaspal S.en_US
dc.contributor.authorKoskinen, Seppoen_US
dc.contributor.authorKristiansson, Katien_US
dc.contributor.authorKutalik, Zoltanen_US
dc.contributor.authorLaan, Marisen_US
dc.contributor.authorLarson, Martyen_US
dc.contributor.authorLauner, Lenore J.en_US
dc.contributor.authorLehne, Benjaminen_US
dc.contributor.authorLehtimäki, Terhoen_US
dc.contributor.authorLiewald, David C. M.en_US
dc.contributor.authorLin, Lien_US
dc.contributor.authorLind, Larsen_US
dc.contributor.authorLindgren, Cecilia M.en_US
dc.contributor.authorLiu, YongMeien_US
dc.contributor.authorLoos, Ruth J. F.en_US
dc.contributor.authorLopez, Lorna M.en_US
dc.contributor.authorLu, Yingchangen_US
dc.contributor.authorLyytikäinen, Leo-Pekkaen_US
dc.contributor.authorMahajan, Anubhaen_US
dc.contributor.authorMamasoula, Chrysovalantoen_US
dc.contributor.authorMarrugat, Jaumeen_US
dc.contributor.authorMarten, Jonathanen_US
dc.contributor.authorMilaneschi, Yurien_US
dc.contributor.authorMorgan, Annaen_US
dc.contributor.authorMorris, Andrew P.en_US
dc.contributor.authorMorrison, Alanna C.en_US
dc.contributor.authorMunson, Peter J.en_US
dc.contributor.authorNalls, Mike A.en_US
dc.contributor.authorNandakumar, Priyankaen_US
dc.contributor.authorNelson, Christopher P.en_US
dc.contributor.authorNiiranen, Teemuen_US
dc.contributor.authorNolte, Ilja M.en_US
dc.contributor.authorNutile, Teresaen_US
dc.contributor.authorOldehinkel, Albertine J.en_US
dc.contributor.authorOostra, Ben A.en_US
dc.contributor.authorO'Reilly, Paul F.en_US
dc.contributor.authorOrg, Elinen_US
dc.contributor.authorPadmanabhan, Sandoshen_US
dc.contributor.authorPalmas, Walteren_US
dc.contributor.authorPalotie, Aarnoen_US
dc.contributor.authorPattie, Alisonen_US
dc.contributor.authorPenninx, Brenda W. J. H.en_US
dc.contributor.authorPerola, Markusen_US
dc.contributor.authorPeters, Annetteen_US
dc.contributor.authorPolasek, Ozrenen_US
dc.contributor.authorPramstaller, Peter P.en_US
dc.contributor.authorNguyen, Quang Trien_US
dc.contributor.authorRaitakari, Olli T.en_US
dc.contributor.authorRen, Meixiaen_US
dc.contributor.authorRettig, Raineren_US
dc.contributor.authorRice, Kennethen_US
dc.contributor.authorRidker, Paul M.en_US
dc.contributor.authorRied, Janina S.en_US
dc.contributor.authorRiese, Harriëtteen_US
dc.contributor.authorRipatti, Samulien_US
dc.contributor.authorRobino, Antoniettaen_US
dc.contributor.authorRose, Lynda M.en_US
dc.contributor.authorRotter, Jerome I.en_US
dc.contributor.authorRudan, Igoren_US
dc.contributor.authorRuggiero, Danielaen_US
dc.contributor.authorSaba, Yasamanen_US
dc.contributor.authorSala, Cinzia F.en_US
dc.contributor.authorSalomaa, Veikkoen_US
dc.contributor.authorSamani, Nilesh J.en_US
dc.contributor.authorSarin, Antti-Pekkaen_US
dc.contributor.authorSchmidt, Reinholden_US
dc.contributor.authorSchmidt, Helenaen_US
dc.contributor.authorShrine, Nicken_US
dc.contributor.authorSiscovick, Daviden_US
dc.contributor.authorSmith, Albert V.en_US
dc.contributor.authorSnieder, Harolden_US
dc.contributor.authorSõber, Siimen_US
dc.contributor.authorSorice, Rossellaen_US
dc.contributor.authorStarr, John M.en_US
dc.contributor.authorStott, David J.en_US
dc.contributor.authorStrachan, David P.en_US
dc.contributor.authorStrawbridge, Rona J.en_US
dc.contributor.authorSundström, Johanen_US
dc.contributor.authorSwertz, Morris A.en_US
dc.contributor.authorTaylor, Kent D.en_US
dc.contributor.authorTeumer, Alexanderen_US
dc.contributor.authorTobin, Martin D.en_US
dc.contributor.authorTomaszewski, Maciejen_US
dc.contributor.authorToniolo, Danielaen_US
dc.contributor.authorTraglia, Michelaen_US
dc.contributor.authorTrompet, Stellaen_US
dc.contributor.authorTuomilehto, Jaakkoen_US
dc.contributor.authorTzourio, Christopheen_US
dc.contributor.authorUitterlinden, André G.en_US
dc.contributor.authorVaez, Ahmaden_US
dc.contributor.authorvan der Most, Peter J.en_US
dc.contributor.authorvan Duijn, Cornelia M.en_US
dc.contributor.authorVergnaud, Anne-Claireen_US
dc.contributor.authorVerwoert, Germaine C.en_US
dc.contributor.authorVitart, Veroniqueen_US
dc.contributor.authorVölker, Uween_US
dc.contributor.authorVollenweider, Peteren_US
dc.contributor.authorVuckovic, Draganaen_US
dc.contributor.authorWatkins, Hughen_US
dc.contributor.authorWild, Sarah H.en_US
dc.contributor.authorWillemsen, Gonnekeen_US
dc.contributor.authorWilson, James F.en_US
dc.contributor.authorWright, Alan F.en_US
dc.contributor.authorYao, Jieen_US
dc.contributor.authorZemunik, Tatijanaen_US
dc.contributor.authorZhang, Weihuaen_US
dc.contributor.authorAttia, John R.en_US
dc.contributor.authorButterworth, Adam S.en_US
dc.contributor.authorChasman, Daniel I.en_US
dc.contributor.authorConen, Daviden_US
dc.contributor.authorCucca, Francescoen_US
dc.contributor.authorDanesh, Johnen_US
dc.contributor.authorHayward, Carolineen_US
dc.contributor.authorHowson, Joanna M. M.en_US
dc.contributor.authorLaakso, Markkuen_US
dc.contributor.authorLakatta, Edward G.en_US
dc.contributor.authorLangenberg, Claudiaen_US
dc.contributor.authorMelander, Olleen_US
dc.contributor.authorMook-Kanamori, Dennis O.en_US
dc.contributor.authorPalmer, Colin N. A.en_US
dc.contributor.authorRisch, Lorenzen_US
dc.contributor.authorScott, Robert A.en_US
dc.contributor.authorScott, Rodney J.en_US
dc.contributor.authorSever, Peteren_US
dc.contributor.authorSpector, Tim D.en_US
dc.contributor.authorvan der Harst, Pimen_US
dc.contributor.authorWareham, Nicholas J.en_US
dc.contributor.authorZeggini, Eleftheriaen_US
dc.contributor.authorLevy, Danielen_US
dc.contributor.authorMunroe, Patricia B.en_US
dc.contributor.authorNewton-Cheh, Christopheren_US
dc.contributor.authorBrown, Morris J.en_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorHung, Adriana M.en_US
dc.contributor.authorO'Donnell, Christopher J.en_US
dc.contributor.authorEdwards, Todd L.en_US
dc.contributor.authorPsaty, Bruce M.en_US
dc.contributor.authorTzoulaki, Ioannaen_US
dc.contributor.authorBarnes, Michael R.en_US
dc.contributor.authorWain, Louise V.en_US
dc.contributor.authorElliott, Paulen_US
dc.contributor.authorCaulfield, Mark J.en_US
dc.date.accessioned2020-05-13T05:04:33Z-
dc.date.available2020-05-13T05:04:33Z-
dc.date.issued2018-
dc.identifier.citationEvangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., . . . Caulfield, M. J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50(10), 1412-1425. doi:10.1038/s41588-018-0205-xen_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttps://hdl.handle.net/10356/138835-
dc.description.abstractHigh blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.description.sponsorshipMOH (Min. of Health, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofNature Geneticsen_US
dc.rights© 2018 The Author(s) (Nature Publishing Group). All rights reserved.en_US
dc.subjectScience::Medicineen_US
dc.titleGenetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traitsen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1038/s41588-018-0205-x-
dc.identifier.pmid30224653-
dc.identifier.scopus2-s2.0-85053701561-
dc.identifier.issue10en_US
dc.identifier.volume50en_US
dc.identifier.spage1412en_US
dc.identifier.epage1425en_US
dc.subject.keywordsCardiovascular Diseasesen_US
dc.subject.keywordsGenome Informaticsen_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
Appears in Collections:LKCMedicine Journal Articles

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