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Title: Sungeidines from a non-canonical enediyne biosynthetic pathway
Authors: Low, Zhen Jie
Ma, Guang-Lei
Tran, Hoa Thi
Zou, Yike
Xiong, Juan
Pang, Limei
Nuryyeva, Selbi
Ye, Hong
Hu, Jin-Feng
Houk, K. N.
Liang, Zhao-Xun
Keywords: Science::Biological sciences::Microbiology
Science::Biological sciences::Biochemistry
Issue Date: 2020
Source: Low, Z. J., Ma, G.-L., Tran, H. T., Zou, Y., Xiong, J., Pang, L., . . . Liang, Z.-X. (2020). Sungeidines from a non-canonical enediyne biosynthetic pathway. Journal of the American Chemical Society, 142(4), 1673-1679. doi:10.1021/jacs.9b10086
Project: NRF-SBP-01
Journal: Journal of the American Chemical Society
Abstract: We report the genome-guided discovery of sungeidines, a class of microbial secondary metabolites with unique structural features. Despite evolutionary relationships with dynemicin-type enediynes, the sungeidines are produced by a biosynthetic gene cluster (BGC) that exhibits distinct differences from known enediyne BGCs. Our studies suggest that the sungeidines are assembled from two octaketide chains that are processed differently than those of the dynemicin-type enediynes. The biosynthesis also involves a unique activating sulfotransferase that promotes a dehydration reaction. The loss of genes, including a putative epoxidase gene, is likely to be the main cause of the divergence of the sungeidine pathway from other canonical enediyne pathways. The findings disclose the surprising evolvability of enediyne pathways and set the stage for characterizing the intriguing enzymatic steps in sungeidine biosynthesis.
ISSN: 0002-7863
DOI: 10.1021/jacs.9b10086
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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