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|Title:||Sungeidines from a non-canonical enediyne biosynthetic pathway||Authors:||Low, Zhen Jie
Tran, Hoa Thi
Houk, K. N.
|Issue Date:||2020||Source:||Low, Z. J., Ma, G.-L., Tran, H. T., Zou, Y., Xiong, J., Pang, L., . . . Liang, Z.-X. (2020). Sungeidines from a non-canonical enediyne biosynthetic pathway. Journal of the American Chemical Society, 142(4), 1673-1679. doi:10.1021/jacs.9b10086||Project:||NRF-SBP-01||Journal:||Journal of the American Chemical Society||Abstract:||We report the genome-guided discovery of sungeidines, a class of microbial secondary metabolites with unique structural features. Despite evolutionary relationships with dynemicin-type enediynes, the sungeidines are produced by a biosynthetic gene cluster (BGC) that exhibits distinct differences from known enediyne BGCs. Our studies suggest that the sungeidines are assembled from two octaketide chains that are processed differently than those of the dynemicin-type enediynes. The biosynthesis also involves a unique activating sulfotransferase that promotes a dehydration reaction. The loss of genes, including a putative epoxidase gene, is likely to be the main cause of the divergence of the sungeidine pathway from other canonical enediyne pathways. The findings disclose the surprising evolvability of enediyne pathways and set the stage for characterizing the intriguing enzymatic steps in sungeidine biosynthesis.||URI:||https://hdl.handle.net/10356/138953||ISSN:||0002-7863||DOI:||10.1021/jacs.9b10086||Rights:||This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.9b10086||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SBS Journal Articles|
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Updated on Aug 2, 2021
Updated on Aug 2, 2021
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