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Title: Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin
Authors: Low, Zhen Jie
Xiong, Juan
Xie, Ying
Ma, Guang-Lei
Saw, Howard
Tran, Hoa Thi
Wong, Soo Lin
Pang, Li Mei
Fong, July
Lu, Peng
Hu, Jin-Feng
Liang, Yang
Miao, Yansong
Liang, Zhao-Xun
Keywords: Science::Biological sciences::Biochemistry
Science::Biological sciences::Microbiology
Issue Date: 2019
Source: Low, Z. J., Xiong, J., Xie, Y., Ma, G.-L., Saw, H., Tran, H. T., . . . Liang, Z.-X. (2020). Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin. Chemical Communications, 56(5), 822-825. doi:10.1039/c9cc08908j
Project: NRF-SBP-01 
Journal: Chemical Communications 
Abstract: Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.
ISSN: 1359-7345
DOI: 10.1039/c9cc08908j
Rights: © 2020 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles
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