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Title: Assessment of choroidal blood flow using laser speckle flowgraphy
Authors: Calzetti, Giacomo
Fondi, Klemens
Bata, Ahmed M.
Luft, Nikolaus
Wozniak, Piotr A.
Witkowska, Katarzyna J.
Bolz, Matthias
Popa-Cherecheanu, Alina
Werkmeister, René M.
Schmidl, Doreen
Garhöfer, Gerhard
Schmetterer, Leopold
Keywords: Science::Medicine
Issue Date: 2018
Source: Calzetti, G., Fondi, K., Bata, A. M., Luft, N., Wozniak, P. A., Witkowska, K. J., . . ., Schmetterer, L. (2018). Assessment of choroidal blood flow using laser speckle flowgraphy. British journal of ophthalmology, 102(12), 1679–1683. doi:10.1136/bjophthalmol-2017-311750
Journal: British journal of ophthalmology
Abstract: Background/aims There is considerable interest in novel techniques to quantify choroidal blood flow (CBF) in humans. In the present study, we investigated a novel technique to measure CBF based on laser speckle flowgraphy (LSFG) in healthy subjects. Methods This study included 31 eyes of 31 healthy, non-smoking subjects aged between 19 and 74 years. A commercial LSFG instrument was used to measure choroidal vessel diameter (CVD) and relative flow volume (RFV) in choroidal vessels that were identified on fundus photos, an approach that was used previously only for retinal vessels. The reproducibility and the effect of isometric exercise on these parameters were investigated. The latter was compared with measurement of subfoveal CBF using laser Doppler flowmetry (LDF). Results Intraclass correlation coefficients for CVD and RFV were higher than 0.8 indicating excellent reproducibility. During isometric exercise, we observed an increase in ocular perfusion pressure of approximately 60% (P<0.001). The increase in RFV and CBF was lower, but also highly significant versus baseline (at minute 6 of isometric exercise: RFV 10.5%±4.2%, CBF 8.3%±3.6%; P<0.001 each) indicating choroidal autoregulation. Conclusion LSFG may be a novel approach to study blood flow in choroidal vessels. Data are reproducible and show good agreement with LDF data.
ISSN: 0007-1161
DOI: 10.1136/bjophthalmol-2017-311750
Rights: © 2018 The Author(s). This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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