Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/139028
Title: Cobalt-catalyzed directed : ortho-methylation of arenes with methyl tosylate
Authors: Sun, Qiao
Yoshikai, Naohiko
Keywords: Science::Chemistry
Issue Date: 2018
Source: Sun, Q., & Yoshikai, N. (2018). Cobalt-catalyzed directed : ortho-methylation of arenes with methyl tosylate. Organic Chemistry Frontiers, 5(14), 2214-2218. doi:10.1039/c8qo00438b
Journal: Organic Chemistry Frontiers
Abstract: A cobalt-catalyzed directed ortho C-H methylation reaction of arenes has been achieved using readily available methyl tosylate as a methylating agent. An in situ-generated cobalt-N-heterocyclic carbene catalyst in combination with neopentylmagnesium bromide promotes the methylation at room temperature. The reaction is applicable to various substrates bearing nitrogen directing groups such as N-aryl imine, N-H imine, and 2-pyridyl groups. The present protocol also allows for facile introduction of a trideuteriomethyl group into arenes.
URI: https://hdl.handle.net/10356/139028
ISSN: 2052-4110
DOI: 10.1039/c8qo00438b
Schools: School of Physical and Mathematical Sciences 
Rights: © 2018 The Partner Organisations. All rights reserved. This paper was published in Organic Chemistry Frontiers and is made available with permission of The Partner Organisations.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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