Please use this identifier to cite or link to this item:
Title: Cobalt-catalyzed directed : ortho-methylation of arenes with methyl tosylate
Authors: Sun, Qiao
Yoshikai, Naohiko
Keywords: Science::Chemistry
Issue Date: 2018
Source: Sun, Q., & Yoshikai, N. (2018). Cobalt-catalyzed directed : ortho-methylation of arenes with methyl tosylate. Organic Chemistry Frontiers, 5(14), 2214-2218. doi:10.1039/c8qo00438b
Journal: Organic Chemistry Frontiers
Abstract: A cobalt-catalyzed directed ortho C-H methylation reaction of arenes has been achieved using readily available methyl tosylate as a methylating agent. An in situ-generated cobalt-N-heterocyclic carbene catalyst in combination with neopentylmagnesium bromide promotes the methylation at room temperature. The reaction is applicable to various substrates bearing nitrogen directing groups such as N-aryl imine, N-H imine, and 2-pyridyl groups. The present protocol also allows for facile introduction of a trideuteriomethyl group into arenes.
ISSN: 2052-4110
DOI: 10.1039/c8qo00438b
Schools: School of Physical and Mathematical Sciences 
Rights: © 2018 The Partner Organisations. All rights reserved. This paper was published in Organic Chemistry Frontiers and is made available with permission of The Partner Organisations.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

Files in This Item:
File Description SizeFormat 
Cobalt-catalyzed directed ortho-methylation.pdf1.04 MBAdobe PDFThumbnail

Citations 20

Updated on Jun 15, 2024

Web of ScienceTM
Citations 20

Updated on Oct 28, 2023

Page view(s)

Updated on Jun 15, 2024

Download(s) 50

Updated on Jun 15, 2024

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.