Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/139034
Title: Copper and secondary amine‐catalyzed pyridine synthesis from o‐acetyl oximes and α,β-unsaturated aldehydes
Authors: Tan, Wei Wen
Wu, Bin
Wei, Ye
Yoshikai, Naohiko
Keywords: Science::Chemistry
Issue Date: 2019
Source: Tan, W. W., Wu, B., Wei, Y., & Yoshikai, N. (2018). Copper and secondary amine‐catalyzed pyridine synthesis from o‐acetyl oximes and α,β-unsaturated aldehydes. Organic Syntheses, 95, 1-14. doi:10.1002/0471264229.os095.01
Journal: Organic Syntheses
Abstract: A. Acetophenone O-acetyl oxime (1). A 250-mL, two-necked roundbottomed flask equipped with a Teflon-coated magnetic stir bar (oval, 20 x 10 mm) is charged with acetophenone (9.33 mL, 80.0 mmol, 1 equiv) (Note 2), pyridine (18 mL, 223 mmol, 2.8 equiv) (Note 3), ethanol (40 mL) (Note 4), and hydroxylamine hydrochloride (8.33 g, 120 mmol, 1.5 equiv) (Note 5). The resulting mixture is stirred at 60 °C for 75 min (Notes 6 and 7) (Figure 1) and then cooled to 22 °C. Water (80 mL) is added, and the resulting biphasic mixture is transferred to a 500-mL separatory funnel.
URI: https://hdl.handle.net/10356/139034
ISBN: 9780471264224
ISSN: 0078-6209
DOI: 10.1002/0471264229.os095.01
Rights: © 2018 Organic Syntheses. All rights reserved. This paper was published in Organic Syntheses and is made available with permission of Organic Syntheses.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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