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https://hdl.handle.net/10356/139103| Title: | Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC | Authors: | Mishra, Rajashree Åkerlund, Mikael Cousminer, Diana L. Ahlqvist, Emma Bradfield, Jonathan P. Chesi, Alessandra Hodge, Kenyaita M. Guy, Vanessa C. Brillon, David J. Pratley, Richard E. Rickels, Michael R. Vella, Adrian Ovalle, Fernando Harris, Ronald I. Melander, Olle Varvel, Stephen Hakonarson, Hakon Froguel, Phillippe Lonsdale, John T. Mauricio, Didac Schloot, Nanette C. Khunti, Kamlesh Greenbaum, Carla J. Yderstræde, Knud B. Tuomi, Tiinamaija Voight, Benjamin F. Schwartz, Stanley Boehm, Bernhard Otto Groop, Leif Leslie, Richard David Grant, Struan F. A. |
Keywords: | Science::Medicine | Issue Date: | 2020 | Source: | Mishra, R., Åkerlund, M., Cousminer, D. L., Ahlqvist, E., Bradfield, J. P., Chesi, A., . . ., Grant, S. F. A. (2020). Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC. Diabetes care, 43(2), 418-425. doi:10.2337/dc19-0986 | Journal: | Diabetes care | Abstract: | The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic discriminators between the two subtypes within this region. | URI: | https://hdl.handle.net/10356/139103 | ISSN: | 1935-5548 | DOI: | 10.2337/dc19-0986 | Rights: | © 2019 American Diabetes Association (ADA). All rights reserved. This paper was published in Diabetes care and is made available with permission of American Diabetes Association (ADA). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Genetic discrimination between LADA and type 1 diabetes within the MHC.pdf | 1.33 MB | Adobe PDF |  View/Open |
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