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Title: Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC
Authors: Mishra, Rajashree
Åkerlund, Mikael
Cousminer, Diana L.
Ahlqvist, Emma
Bradfield, Jonathan P.
Chesi, Alessandra
Hodge, Kenyaita M.
Guy, Vanessa C.
Brillon, David J.
Pratley, Richard E.
Rickels, Michael R.
Vella, Adrian
Ovalle, Fernando
Harris, Ronald I.
Melander, Olle
Varvel, Stephen
Hakonarson, Hakon
Froguel, Phillippe
Lonsdale, John T.
Mauricio, Didac
Schloot, Nanette C.
Khunti, Kamlesh
Greenbaum, Carla J.
Yderstræde, Knud B.
Tuomi, Tiinamaija
Voight, Benjamin F.
Schwartz, Stanley
Boehm, Bernhard Otto
Groop, Leif
Leslie, Richard David
Grant, Struan F. A.
Keywords: Science::Medicine
Issue Date: 2020
Source: Mishra, R., Åkerlund, M., Cousminer, D. L., Ahlqvist, E., Bradfield, J. P., Chesi, A., . . ., Grant, S. F. A. (2020). Genetic discrimination between LADA and childhood-onset type 1 diabetes within the MHC. Diabetes care, 43(2), 418-425. doi:10.2337/dc19-0986
Journal: Diabetes care
Abstract: The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic discriminators between the two subtypes within this region.
ISSN: 1935-5548
DOI: 10.2337/dc19-0986
Rights: © 2019 American Diabetes Association (ADA). All rights reserved. This paper was published in Diabetes care and is made available with permission of American Diabetes Association (ADA).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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