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Title: Clinical trial supply chain design based on the Pareto-optimal trade-off between time and cost
Authors: Zhao, Hui
Wu, Kan
Huang, Edward
Keywords: Engineering::Mechanical engineering
Issue Date: 2018
Source: Zhao, H., Wu, K., & Huang, E. (2018). Clinical trial supply chain design based on the Pareto-optimal trade-off between time and cost. IISE Transactions, 50(6), 512-524. doi:10.1080/24725854.2017.1395978
Journal: IISE Transactions
Abstract: Long duration and high cost are two key characteristics of clinical trials. Since the clinical trial duration is part of the limited patent life and determines the time to market, its reduction is of critical importance. Although the duration can be reduced through increasing the number of clinical sites in the supply chain, the total enrollment and operational costs are also increased. Hence, Pareto-optimal supply chain configurations are used to improve clinical trial efficiency. In this study, we propose a multi-objective clinical site selection model that considers the trade-off between time and cost of clinical trials. An efficiency curve representing the Pareto-optimal trade-off is provided for decision makers to design the supply chain. To identify all Pareto-optimal supply chain configurations efficiently, we develop an algorithm based on proposed propositions. The optimality cuts are derived to improve the solving efficiency of this problem.
ISSN: 2472-5854
DOI: 10.1080/24725854.2017.1395978
Rights: © 2018 IISE (Published by Taylor & Francis). All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MAE Journal Articles

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