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Title: Nanophotonic array-induced dynamic behavior for label-free shape-selective bacteria sieving
Authors: Shi, Yuzhi
Zhao, Haitao
Nguyen, Kim Truc
Zhang, Yi
Chin, Lip Ket
Zhu, Tongtong
Yu, Yefeng
Cai, Hong
Yap, Peng Huat
Liu, Patricia Yang
Xiong, Sha
Zhang, Jingbo
Qiu, Cheng-Wei
Chan, Che Ting
Liu, Ai Qun
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2019
Source: Shi, Y., Zhao, H., Nguyen, K. T., Zhang, Y., Chin, L. K., Zhu, T., . . . Liu, A. Q. (2019). Nanophotonic array-induced dynamic behavior for label-free shape-selective bacteria sieving. ACS Nano, 13(10), 12070-12080. doi:10.1021/acsnano.9b06459
Project: NRF-CRP13-2014-01
Journal: ACS Nano
Abstract: Current particle sorting methods such as microfluidics, acoustics, and optics focus on exploiting the differences in the mass, size, refractive index, or fluorescence staining. However, there exist formidable challenges for them to sort label-free submicron particles with similar volume and refractive index yet distinct shapes. In this work, we report an optofluidic nanophotonic sawtooth array (ONSA) that generates sawtooth-like light fields through light coupling, paving the physical foundation for shape-selective sieving. Submicron particles interact with the coupled hotspots which impose different optical torques on the particles according to their shapes. Unstained S. aureus and E. coli are used as a model system to demonstrate this shape-selective sorting mechanism based on the torque-induced body dynamics, which was previously unattainable by other particle sorting technologies. More than 95% of S. aureus is retained within ONSA, while more than 97% of E. coli is removed. This nanophotonic chip offers a paradigm shift in shape-selective sorting of submicron particles and expands the boundary of optofluidics-based particle manipulation.
ISSN: 1936-0851
DOI: 10.1021/acsnano.9b06459
Schools: School of Electrical and Electronic Engineering 
School of Mechanical and Aerospace Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
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