Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/139182
Title: Chromium(III)-catalyzed addition of water and alcohol to α,β-unsaturated ketones for the synthesis of β-hydroxyl and β-alkoxyl ketones in aqueous media
Authors: Yun, Jin-Jin
Liu, Xuan-Yu
Deng, Wei
Chu, Xue-Qiang
Shen, Zhi-Liang
Loh, Teck-Peng
Keywords: Science::Chemistry
Issue Date: 2018
Source: Yun, J.-J., Liu, X.-Y., Deng, W., Chu, X.-Q., Shen, Z.-L., & Loh, T.-P. (2018). Chromium(III)-catalyzed addition of water and alcohol to α,β-unsaturated ketones for the synthesis of β-hydroxyl and β-alkoxyl ketones in aqueous media. The Journal of Organic Chemistry, 83(18), 10898-10907. doi:10.1021/acs.joc.8b01584
Journal: The Journal of Organic Chemistry
Abstract: An efficient chromium(III) chloride-catalyzed Michael-type reaction of water or alcohol with α,β-unsaturated ketones is developed. A variety of α,β-unsaturated ketones effectively reacted with either water or alcohols to give the corresponding β-hydroxyl ketones or β-alkoxyl ketones in modest to high yields with excellent compatibility to various functional groups. The approach was further utilized for the preparation of synthetically useful compounds containing tetrahydrofuran skeleton.
URI: https://hdl.handle.net/10356/139182
ISSN: 0022-3263
DOI: 10.1021/acs.joc.8b01584
Rights: © 2018 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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