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Title: Synthesis of novel drug-free cancer targeting nanotherapeutics
Authors: Cheong, How Min
Keywords: Engineering::Materials::Biomaterials
Issue Date: 2020
Publisher: Nanyang Technological University
Abstract: Cancer remains the leading cause of death worldwide. Mesoporous silica nanoparticles (MSNs) are seen as one of the promising candidates for anti-cancer therapy, due to its favourable cancer-killing properties. In this research paper, MSNs are being further modified, through attachment of PEG (Polyethylene Glycol) chains, in efforts to increase its ability to cause cancer cell death in-vivo, by reducing aggregation and therefore increasing the stability of MSNs. Preliminary in vitro results indicate that PEG conjugation can significantly enhance the stability of MSN in water as well as physiologically-emulated phosphate-buffered saline (PBS). These data lay a solid foundation for the follow-up fabrication of cancer-targeting physiologically-stable silica nanomedicine.
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:MSE Student Reports (FYP/IA/PA/PI)

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