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Title: A catalytic and selective scissoring molecular tool for quadruplex nucleic acids
Authors: Nadai, Matteo
Doria, Filippo
Scalabrin, Matteo
Pirota, Valentina
Grande, Vincenzo
Bergamaschi, Greta
Amendola, Valeria
Winnerdy, Fernaldo Richtia
Phan, Anh Tuân
Richter, Sara N.
Freccero, Mauro
Keywords: Science::Biological sciences
Issue Date: 2018
Source: Nadai, M., Doria, F., Scalabrin, M., Pirota, V., Grande, V., Bergamaschi, G., . . . Freccero, M. (2018). A catalytic and selective scissoring molecular tool for quadruplex nucleic acids. Journal of the American Chemical Society, 140(44), 14528-14532. doi:10.1021/jacs.8b05337
Journal: Journal of the American Chemical Society
Abstract: A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS. FRET melting, CD, NMR, gel sequencing, and mass spectrometry experiments highlight a unique and unexpected selectivity in cleaving G-quadruplex sequences. This selectivity relies both on the binding affinity and structural features of the targeted G-quadruplexes.
ISSN: 0002-7863
DOI: 10.1021/jacs.8b05337
Rights: © 2018 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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