Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/139344
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLee, Bei Shien_US
dc.contributor.authorPethe, Kevinen_US
dc.date.accessioned2020-05-19T03:20:05Z-
dc.date.available2020-05-19T03:20:05Z-
dc.date.issued2018-
dc.identifier.citationLee, B. S., & Pethe, K. (2018). Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis. Current Opinion in Pharmacology, 42, 22-26. doi:10.1016/j.coph.2018.06.006en_US
dc.identifier.issn1471-4892en_US
dc.identifier.urihttps://hdl.handle.net/10356/139344-
dc.description.abstractIn the field of tuberculosis drug development, the term ‘promiscuous’ was coined to collectively describe targets that repeatedly show up in whole-cell screenings. With the current climate leaning towards the exclusion of these targets in future drug screens, this review discusses and clarifies misconceptions surrounding this classification, the prospects of developing compounds targeting promiscuous targets, and their potential impact on tuberculosis drug development. The dominance of these targets in cell-based screens reflect not only bias introduced by experimental setup, but also some of the pathogen’s greatest vulnerabilities. Coupled with favourable predictions of their in vivo efficacies and synergism with other TB drugs, these targets open opportunities to be explored for the development of rational drug combination for tuberculosis.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.description.sponsorshipMOH (Min. of Health, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofCurrent opinion in pharmacologyen_US
dc.rights© 2018 Elsevier Ltd. All rights reserved. This paper was published in Current opinion in pharmacology and is made available with permission of Elsevier Ltd.en_US
dc.subjectScience::Biological sciences::Molecular biologyen_US
dc.subjectScience::Biological sciences::Biochemistryen_US
dc.titleTherapeutic potential of promiscuous targets in Mycobacterium tuberculosisen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1016/j.coph.2018.06.006-
dc.description.versionAccepted versionen_US
dc.identifier.pmid30015177-
dc.identifier.scopus2-s2.0-85049804810-
dc.identifier.volume42en_US
dc.identifier.spage22en_US
dc.identifier.epage26en_US
dc.subject.keywordsTuberculosisen_US
dc.subject.keywordsPromiscuous Targetsen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:SBS Journal Articles
Files in This Item:
File Description SizeFormat 
Therapeutic potential of promiscuous targets.pdf172.67 kBAdobe PDFView/Open

SCOPUSTM   
Citations 20

11
Updated on Jul 5, 2022

PublonsTM
Citations 20

11
Updated on Jul 7, 2022

Page view(s)

177
Updated on Aug 16, 2022

Download(s) 50

70
Updated on Aug 16, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.