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Title: Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis
Authors: Lee, Bei Shi
Pethe, Kevin
Keywords: Science::Biological sciences::Molecular biology
Science::Biological sciences::Biochemistry
Issue Date: 2018
Source: Lee, B. S., & Pethe, K. (2018). Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis. Current Opinion in Pharmacology, 42, 22-26. doi:10.1016/j.coph.2018.06.006
Journal: Current opinion in pharmacology
Abstract: In the field of tuberculosis drug development, the term ‘promiscuous’ was coined to collectively describe targets that repeatedly show up in whole-cell screenings. With the current climate leaning towards the exclusion of these targets in future drug screens, this review discusses and clarifies misconceptions surrounding this classification, the prospects of developing compounds targeting promiscuous targets, and their potential impact on tuberculosis drug development. The dominance of these targets in cell-based screens reflect not only bias introduced by experimental setup, but also some of the pathogen’s greatest vulnerabilities. Coupled with favourable predictions of their in vivo efficacies and synergism with other TB drugs, these targets open opportunities to be explored for the development of rational drug combination for tuberculosis.
ISSN: 1471-4892
DOI: 10.1016/j.coph.2018.06.006
Rights: © 2018 Elsevier Ltd. All rights reserved. This paper was published in Current opinion in pharmacology and is made available with permission of Elsevier Ltd.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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