Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/139433
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dc.contributor.authorHu, Kanen_US
dc.contributor.authorAn, Jianingen_US
dc.contributor.authorYoon, Yong-Jinen_US
dc.date.accessioned2020-05-19T07:59:56Z-
dc.date.available2020-05-19T07:59:56Z-
dc.date.issued2018-
dc.identifier.citationHu, K., An, J., & Yoon, Y.-J. (2018). Two-wavelength, photo-initiation and photo-inhibition competing for selective photo-patterning of hydrogel porous microstructures. International Journal of Precision Engineering and Manufacturing, 19(5), 729-735. doi:10.1007/s12541-018-0087-yen_US
dc.identifier.issn2234-7593en_US
dc.identifier.urihttps://hdl.handle.net/10356/139433-
dc.description.abstractEver since its development, tissue engineering has played a significant role in the medical arena with an ever-growing demand for various tissue donations. One crucial factor in conducting in vitro tissue engineering study is the construction of a desirable artificial three-dimensional (3D) hydrogel tissue scaffold to act as the extracellular matrix (ECM), meeting the complex requirements for specific cell cultures. Existing hydrogel scaffold fabrication techniques and systems utilized in constructing ECM are either twodimensionally limiting, hard to control the pattern morphologies or expensive and time consuming. In the present study, we introduce a simple, inexpensive method for selective patterning 3D porous microstructures. This technique-'two wavelength photo-initiation and photo inhibition competes’ is an extension of conventional photo-patterning method. Integrating with shadow mask, photo inhibition radicals were introduced to couple with the polymerization chains and terminate the photo crosslinking behavior at designed region, making 3D selectively patterning hydrogel feasible. High aspect ratio ridge with selectively inhibited porous structures and selectively patterned micro pillar were fabricated using this method within 1 minute. The in vitro cell test results indicate the patterned structures' good biocompatibility.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Precision Engineering and Manufacturingen_US
dc.rights© 2018 KSPE and Springer (Published by Springer). All rights reserved.en_US
dc.subjectEngineering::Mechanical engineeringen_US
dc.titleTwo-wavelength, photo-initiation and photo-inhibition competing for selective photo-patterning of hydrogel porous microstructuresen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.researchSingapore-MIT Alliance Programmeen_US
dc.identifier.doi10.1007/s12541-018-0087-y-
dc.identifier.scopus2-s2.0-85047221530-
dc.identifier.issue5en_US
dc.identifier.volume19en_US
dc.identifier.spage729en_US
dc.identifier.epage735en_US
dc.subject.keywordsHydrogelen_US
dc.subject.keywordsMicrostructuresen_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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