Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/139496
Title: 3D Chromosome Modelling with Hi-C data
Authors: Koh, Qi Cheng
Keywords: Science::Mathematics::Applied mathematics
Issue Date: 2020
Publisher: Nanyang Technological University
Abstract: 3-Dimensional Chromosome Modeling has been a extensively researched topic due to the link between its structural configuration and its many functions such as the regulation of gene expression and more. Many articles have explored the different ways to use data from chromosome conformation capturing data to model the chromosomes. Some articles use probabilistic methods by analysing interaction frequencies directly while some use non-stochastic methods where they convert these interaction frequencies to distances to reconstruct the 3-D structures. Different papers have varying success in modeling chromosomes, however, this article aims to provide readers with a non-stochastic method to model chromosomes using Hi-C data. The task to do so is made out of two components mainly the conversion from interaction frequencies to corresponding distances and finding the nearest distance matrix to the actual structures.
URI: https://hdl.handle.net/10356/139496
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
3D_Chromosome_Modeling_with_Hi_C_Data (3).pdf
  Restricted Access
532.97 kBAdobe PDFView/Open

Page view(s)

240
Updated on May 15, 2022

Download(s) 50

28
Updated on May 15, 2022

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.