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Title: Graphene materials in antimicrobial nanomedicine : current status and future perspectives
Authors: Karahan, Hüseyin Enis
Wiraja, Christian
Xu, Chenjie
Wei, Jun
Wang, Yilei
Wang, Liang
Liu, Fei
Chen, Yuan
Keywords: Engineering::Bioengineering
Issue Date: 2018
Source: Karahan, H. E., Wiraja, C., Xu, C., Wei, J., Wang, Y., Wang, L., . . . Chen, Y. (2018). Graphene materials in antimicrobial nanomedicine : current status and future perspectives. Advanced Healthcare Materials, 7(13), 1701406-. doi:10.1002/adhm.201701406
Journal: Advanced Healthcare Materials
Abstract: Graphene materials (GMs), such as graphene, graphene oxide (GO), reduced GO (rGO), and graphene quantum dots (GQDs), are rapidly emerging as a new class of broad‐spectrum antimicrobial agents. This report describes their state‐of‐the‐art and potential future covering both fundamental aspects and biomedical applications. First, the current understanding of the antimicrobial mechanisms of GMs is illustrated, and the complex picture of underlying structure–property–activity relationships is sketched. Next, the different modes of utilization of antimicrobial GMs are explained, which include their use as colloidal dispersions, surface coatings, and photothermal/photodynamic therapy agents. Due to their practical relevance, the examples where GMs function as synergistic agents or release platforms for metal ions and/or antibiotic drugs are also discussed. Later, the applicability of GMs in the design of wound dressings, infection‐protective coatings, and antibiotic‐like formulations (“nanoantibiotics”) is assessed. Notably, to support our assessments, the existing clinical applications of conventional carbon materials are also evaluated. Finally, the key hurdles of the field are highlighted, and several possible directions for future investigations are proposed. We hope that the roadmap provided here will encourage researchers to tackle remaining challenges toward clinical translation of promising research findings and help realize the potential of GMs in antimicrobial nanomedicine.
ISSN: 2192-2640
DOI: 10.1002/adhm.201701406
Rights: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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