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Title: Single molecule manipulation of nucleic acid structures using optical tweezers
Authors: Tan, Kwan Ann
Keywords: Science::Biological sciences::Biophysics
Issue Date: 2020
Publisher: Nanyang Technological University
Abstract: Optical tweezers are versatile and precise tools that are well suited for single molecule studies. Here, optical tweezers is used to study the mechanical unfolding of five RNA structures. The studying of mechanical unfolding is crucial to understand the many cellular processes that involves RNA, like translation. We find that hairpin-like structures can unfold reversibly at pH 7.3.
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Student Reports (FYP/IA/PA/PI)

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