Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140056
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dc.contributor.authorLim, Hwee Yingen_US
dc.contributor.authorLim, Sheau Yngen_US
dc.contributor.authorTan, Chek Kunen_US
dc.contributor.authorThiam, Chung Hweeen_US
dc.contributor.authorGoh, Chi Chingen_US
dc.contributor.authorCarbajo, Danielen_US
dc.contributor.authorChew, Samantha Hui Shangen_US
dc.contributor.authorSee, Peter Chi Eeen_US
dc.contributor.authorChakarov, Svetoslaven_US
dc.contributor.authorWang, Xiao Nongen_US
dc.contributor.authorLim, Li Huien_US
dc.contributor.authorJohnson, Louise A.en_US
dc.contributor.authorLum, Josephineen_US
dc.contributor.authorFong, Chui Yeeen_US
dc.contributor.authorAriff Bongsoen_US
dc.contributor.authorArijit Biswasen_US
dc.contributor.authorGoh, Chernen_US
dc.contributor.authorEvrard, Maximilienen_US
dc.contributor.authorYeo, Kim Pinen_US
dc.contributor.authorBasu, Ranuen_US
dc.contributor.authorWang, Jun Kiten_US
dc.contributor.authorTan, Yingrouen_US
dc.contributor.authorRohit Jainen_US
dc.contributor.authorTikoo, Shwetaen_US
dc.contributor.authorChoong, Cleo S. N.en_US
dc.contributor.authorWeninger, Wolfgangen_US
dc.contributor.authorPoidinger, Michaelen_US
dc.contributor.authorStanley, Richard Een_US
dc.contributor.authorCollin, Matthewen_US
dc.contributor.authorTan, Nguan Soonen_US
dc.contributor.authorNg, Lai Guanen_US
dc.contributor.authorJackson, David G.en_US
dc.contributor.authorGinhoux, Florenten_US
dc.contributor.authorAngeli, Véroniqueen_US
dc.date.accessioned2020-05-26T05:53:38Z-
dc.date.available2020-05-26T05:53:38Z-
dc.date.issued2018-
dc.identifier.citationLim, H. Y., Lim, S. Y., Tan, C. K., Thiam, C. H., Goh, C. C., Carbajo, D., . . . Angeli, V. (2018). Hyaluronan receptor LYVE-1 - expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen. Immunity, 49(2), 326-341. doi:10.1016/j.immuni.2018.06.008en_US
dc.identifier.issn1074-7613en_US
dc.identifier.urihttps://hdl.handle.net/10356/140056-
dc.description.abstractThe maintenance of appropriate arterial tone is critically important for normal physiological arterial function. However, the cellular and molecular mechanisms remain poorly defined. Here, we have shown that in the mouse aorta, resident macrophages prevented arterial stiffness and collagen deposition in the steady state. Using phenotyping, transcriptional profiling, and targeted deletion of Csf1r, we have demonstrated that these macrophages-which are a feature of blood vessels invested with smooth muscle cells (SMCs) in both mouse and human tissues-expressed the hyaluronan (HA) receptor LYVE-l. Furthermore, we have shown they possessed the unique ability to modulate collagen expression in SMCs by matrix metalloproteinase MMP-9-dependent proteolysis through engagement of LYVE-1 with the HA pericellular matrix of SMCs. Our study has unveiled a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofImmunityen_US
dc.rights© 2018 Elsevier Inc. All rights reserved.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleHyaluronan receptor LYVE-1 - expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagenen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.1016/j.immuni.2018.06.008-
dc.identifier.pmid30054204-
dc.identifier.scopus2-s2.0-85051643623-
dc.identifier.issue2en_US
dc.identifier.volume49en_US
dc.identifier.spage326en_US
dc.identifier.epage341en_US
dc.subject.keywordsMacrophageen_US
dc.subject.keywordsLYVE-1en_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
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