Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140056
Title: Hyaluronan receptor LYVE-1 - expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen
Authors: Lim, Hwee Ying
Lim, Sheau Yng
Tan, Chek Kun
Thiam, Chung Hwee
Goh, Chi Ching
Carbajo, Daniel
Chew, Samantha Hui Shang
See, Peter Chi Ee
Chakarov, Svetoslav
Wang, Xiao Nong
Lim, Li Hui
Johnson, Louise A.
Lum, Josephine
Fong, Chui Yee
Ariff Bongso
Arijit Biswas
Goh, Chern
Evrard, Maximilien
Yeo, Kim Pin
Basu, Ranu
Wang, Jun Kit
Tan, Yingrou
Rohit Jain
Tikoo, Shweta
Choong, Cleo S. N.
Weninger, Wolfgang
Poidinger, Michael
Stanley, Richard E
Collin, Matthew
Tan, Nguan Soon
Ng, Lai Guan
Jackson, David G.
Ginhoux, Florent
Angeli, Véronique
Keywords: Science::Biological sciences
Issue Date: 2018
Source: Lim, H. Y., Lim, S. Y., Tan, C. K., Thiam, C. H., Goh, C. C., Carbajo, D., . . . Angeli, V. (2018). Hyaluronan receptor LYVE-1 - expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen. Immunity, 49(2), 326-341. doi:10.1016/j.immuni.2018.06.008
Journal: Immunity
Abstract: The maintenance of appropriate arterial tone is critically important for normal physiological arterial function. However, the cellular and molecular mechanisms remain poorly defined. Here, we have shown that in the mouse aorta, resident macrophages prevented arterial stiffness and collagen deposition in the steady state. Using phenotyping, transcriptional profiling, and targeted deletion of Csf1r, we have demonstrated that these macrophages-which are a feature of blood vessels invested with smooth muscle cells (SMCs) in both mouse and human tissues-expressed the hyaluronan (HA) receptor LYVE-l. Furthermore, we have shown they possessed the unique ability to modulate collagen expression in SMCs by matrix metalloproteinase MMP-9-dependent proteolysis through engagement of LYVE-1 with the HA pericellular matrix of SMCs. Our study has unveiled a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.
URI: https://hdl.handle.net/10356/140056
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2018.06.008
Rights: © 2018 Elsevier Inc. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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