Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140140
Title: A minimal sequence for left‐handed G‐quadruplex formation
Authors: Bakalar, Blaž
Heddi, Brahim
Schmitt, Emmanuelle
Mechulam, Yves
Phan, Anh Tuân
Keywords: Science::Chemistry
Issue Date: 2019
Source: Bakalar, B., Heddi, B., Schmitt, E., Mechulam, Y., & Phan, A. T. (2019). A minimal sequence for left‐handed G‐quadruplex formation. Angewandte Chemie International Edition, 58(8), 2331-2335. doi:10.1002/anie.201812628
Journal: Angewandte Chemie International Edition
Abstract: Recently, we observed the first example of a left‐handed G‐quadruplex structure formed by natural DNA, named Z‐G4 . We analysed the Z‐G4 structure and inspected its primary 28‐nt sequence in order to identify motifs that convey the unique left‐handed twist. Using circular dichroism spectroscopy, NMR spectroscopy, and X‐ray crystallography, we revealed a minimal sequence motif of 12 nt (GTGGTGGTGGTG) for formation of the left‐handed DNA G‐quadruplex, which is found to be highly abundant in the human genome. A systematic analysis of thymine loop mutations revealed a moderate sequence tolerance, which would further broaden the space of sequences prone to left‐handed G‐quadruplex formation.
URI: https://hdl.handle.net/10356/140140
ISSN: 1433-7851
DOI: 10.1002/anie.201812628
Rights: This is the accepted version of the following article: Bakalar, B., Heddi, B., Schmitt, E., Mechulam, Y., & Phan, A. T. (2019). A minimal sequence for left‐handed G‐quadruplex formation. Angewandte Chemie International Edition, 58(8), 2331-2335. doi:10.1002/anie.201812628, which has been published in final form at https://doi.org/10.1002/anie.201812628. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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