Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140168
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dc.contributor.authorTruong, Thi Hong Anhen_US
dc.contributor.authorWinnerdy, Fernaldo Richtiaen_US
dc.contributor.authorPhan, Anh Tuânen_US
dc.date.accessioned2020-05-27T03:38:01Z-
dc.date.available2020-05-27T03:38:01Z-
dc.date.issued2019-
dc.identifier.citationTruong, T. H. A., Winnerdy, F. R., & Phan, A. T. (2019). An unprecedented knot‐like G‐quadruplex peripheral motif. Angewandte Chemie International Edition, 58(39), 13834-13839. doi:10.1002/anie.201907740en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttps://hdl.handle.net/10356/140168-
dc.description.abstractA knot‐like G‐quadruplex peripheral structure is formed by a 7‐nt DNA sequence DL7 (TGTTGGT), in which six out of its seven nucleobases participate in compact base‐pairing interactions. Here, the solution NMR structure of a 24‐nt DNA oligonucleotide containing the DL7 sequence shows the interaction between a two‐layer anti‐parallel G‐quadruplex core and the peripheral knot‐like structure, including the construction of two sharp turns in the DNA backbone. The formation of this novel structural element highlights the intricate properties of single‐stranded DNA folding in presence of G‐quadruplex‐forming motifs. We demonstrated the compatibility of the DL7 knot‐like structure with various G‐quadruplexes, which could have implications in drug design and DNA engineering.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relationNRF-NRFI2017-09en_US
dc.relationMOE2015-T2-1-092en_US
dc.relation.ispartofAngewandte Chemie International Editionen_US
dc.rightsThis is the accepted version of the following article: Truong, T. H. A., Winnerdy, F. R., & Phan, A. T. (2019). An unprecedented knot‐like G‐quadruplex peripheral motif. Angewandte Chemie International Edition, 58(39), 13834-13839. doi:10.1002/anie.201907740, which has been published in final form at https://doi.org/10.1002/anie.201907740. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].en_US
dc.subjectScience::Chemistryen_US
dc.subjectScience::Biological sciencesen_US
dc.titleAn unprecedented knot‐like G‐quadruplex peripheral motifen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.contributor.organizationNTU Institute of Structural Biologyen_US
dc.identifier.doi10.1002/anie.201907740-
dc.description.versionAccepted versionen_US
dc.identifier.pmid31317601-
dc.identifier.scopus2-s2.0-85070916928-
dc.identifier.issue39en_US
dc.identifier.volume58en_US
dc.identifier.spage13834en_US
dc.identifier.epage13839en_US
dc.subject.keywordsBase Pairingen_US
dc.subject.keywordsDNAen_US
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