Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140168
Title: An unprecedented knot‐like G‐quadruplex peripheral motif
Authors: Truong, Thi Hong Anh
Winnerdy, Fernaldo Richtia
Phan, Anh Tuân
Keywords: Science::Chemistry
Science::Biological sciences
Issue Date: 2019
Source: Truong, T. H. A., Winnerdy, F. R., & Phan, A. T. (2019). An unprecedented knot‐like G‐quadruplex peripheral motif. Angewandte Chemie International Edition, 58(39), 13834-13839. doi:10.1002/anie.201907740
Project: NRF-NRFI2017-09
MOE2015-T2-1-092
Journal: Angewandte Chemie International Edition
Abstract: A knot‐like G‐quadruplex peripheral structure is formed by a 7‐nt DNA sequence DL7 (TGTTGGT), in which six out of its seven nucleobases participate in compact base‐pairing interactions. Here, the solution NMR structure of a 24‐nt DNA oligonucleotide containing the DL7 sequence shows the interaction between a two‐layer anti‐parallel G‐quadruplex core and the peripheral knot‐like structure, including the construction of two sharp turns in the DNA backbone. The formation of this novel structural element highlights the intricate properties of single‐stranded DNA folding in presence of G‐quadruplex‐forming motifs. We demonstrated the compatibility of the DL7 knot‐like structure with various G‐quadruplexes, which could have implications in drug design and DNA engineering.
URI: https://hdl.handle.net/10356/140168
ISSN: 1433-7851
DOI: 10.1002/anie.201907740
Rights: This is the accepted version of the following article: Truong, T. H. A., Winnerdy, F. R., & Phan, A. T. (2019). An unprecedented knot‐like G‐quadruplex peripheral motif. Angewandte Chemie International Edition, 58(39), 13834-13839. doi:10.1002/anie.201907740, which has been published in final form at https://doi.org/10.1002/anie.201907740. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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