Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140180
Title: Recent advances in radical-initiated C(sp3) – H bond oxidative functionalization of alkyl nitriles
Authors: Chu, Xue-Qiang
Ge, Danhua
Shen, Zhi-Liang
Loh, Teck-Peng
Keywords: Science::Chemistry
Issue Date: 2017
Source: Chu, X.-Q., Ge, D., Shen, Z.-L., & Loh, T.-P. (2018). Recent advances in radical-initiated C(sp3) – H bond oxidative functionalization of alkyl nitriles. ACS Catalysis, 8(1), 258-271. doi:10.1021/acscatal.7b03334
Journal: ACS Catalysis
Abstract: Chemoselective functionalizations of intrinsically less reactive C(sp3)–H bonds of alkyl nitriles are of particular interest to the chemical community because these strategies provide opportunities for the introduction of important cyanoalkyl groups onto target frameworks in a step-economical fashion. In recent years, the introduction of nitrile-containing alkyl radicals in tandem radical additions and oxidative couplings has inarguably brought chemists a new radical reaction platform for the diverse synthesis of natural products and pharmaceuticals. Compared with the wide applications of various C-centered radicals adjacent to a heteroatom, however, nitrile-containing alkyl radicals remain largely unexplored. New methods for C(sp3)–H bond oxidative functionalization of alkyl nitriles and new mechanistic manifolds would result in the development of a broad range of novel reactions. Therefore, this review will give an overview of various types of radical cyanoalkylation using the key alkyl nitrile reactants, which lie beyond traditional coupling chemistry.
URI: https://hdl.handle.net/10356/140180
ISSN: 2155-5435
DOI: 10.1021/acscatal.7b03334
Schools: School of Physical and Mathematical Sciences 
Rights: © 2017 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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