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Title: Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes
Authors: Limwongyut, Jakarin
Liu, Yang
Chilambi, Gayatri Shankar
Seviour, Thomas
Hinks, Jamie
Mu, Yuguang
Bazan, Guillermo C.
Keywords: Engineering::Bioengineering
Issue Date: 2018
Source: Limwongyut, J., Liu, Y., Chilambi, G. S., Seviour, T., Hinks, J., Mu, Y., & Bazan, G. C. (2018). Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes. RSC Advances, 8(70), 39849-39853. doi:10.1039/c8ra08069k
Journal: RSC Advances
Abstract: A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, compared to its linear analog (COE2-3C), COE2-3-pCp introduces more lipid disorder with higher extent of membrane thinning. COE2-3-pCp also exhibits a higher MIC towards E. coli K12 and yeast, while maintaining similar levels of membrane permeabilization. These findings suggest a new design of COEs as biocompatible cell permeabilizers.
ISSN: 2046-2069
DOI: 10.1039/C8RA08069K
Rights: © 2018 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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