Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140698
Title: Hydrolytic stability of methacrylamide and methacrylate in gelatin methacryloyl and decoupling of gelatin methacrylamide from gelatin methacryloyl through hydrolysis
Authors: Zheng, Jing
Zhu, Mengxiang
Ferracci, Gaia
Cho, Nam-Joon
Lee, Bae Hoon
Keywords: Engineering::Materials
Issue Date: 2018
Source: Zheng, J., Zhu, M., Ferracci, G., Cho, N.-J., & Lee, B. H. (2018). Hydrolytic stability of methacrylamide and methacrylate in gelatin methacryloyl and decoupling of gelatin methacrylamide from gelatin methacryloyl through hydrolysis. Macromolecular Chemistry and Physics, 219(18), 1800266-. doi:10.1002/macp.201800266
Journal: Macromolecular Chemistry and Physics
Abstract: Gelatin methacryloyl (GelMA; GM) is a promising nature-derived photocurable material that can mimic the extracellular matrix because GelMA features tailorable mechanical properties, proteolytic degradation, and good cell adhesion. GelMA contains not only methacrylamide but also methacrylate. However, the hydrolytic stability of methacrylamide and methacrylate groups of GelMA in aqueous solutions has not been scrutinized. Here, the structural change of GelMA through hydrolysis is investigated for the first time. The structural change of hydrolyzed GelMA is quantitatively identified using colorimetric and 1H NMR methods. The methacrylate groups decompose markedly at high pH solutions, but the methacrylamide groups remain stable. Further, pure gelatin methacrylamide is successfully decoupled from GelMA for a better understanding of GelMA structure and future use for biomedical applications.
URI: https://hdl.handle.net/10356/140698
ISSN: 1022-1352
DOI: 10.1002/macp.201800266
Rights: This is the accepted version of the following article: Zheng, J., Zhu, M., Ferracci, G., Cho, N.-J., & Lee, B. H. (2018). Hydrolytic stability of methacrylamide and methacrylate in gelatin methacryloyl and decoupling of gelatin methacrylamide from gelatin methacryloyl through hydrolysis. Macromolecular Chemistry and Physics, 219(18), 1800266-, which has been published in final form at dx.doi.org/10.1002/macp.201800266. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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