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Title: Zika virus protease : an antiviral drug target
Authors: Kang, CongBao
Keller, Thomas H.
Luo, Dahai
Keywords: Science::Medicine
Issue Date: 2017
Source: Kang, C., Keller, T. H., & Luo, D. (2017). Zika virus protease : an antiviral drug target. Trends in Microbiology, 25(10), 797-808. doi:10.1016/j.tim.2017.07.001
Journal: Trends in Microbiology
Abstract: The recent outbreak of Zika virus (ZIKV) infection has caused global concern due to its link to severe damage to the brain development of foetuses and neuronal complications in adult patients. A worldwide research effort has been undertaken to identify effective and safe treatment and vaccination options. Among the proposed viral and host components, the viral NS2B-NS3 protease represents an attractive drug target due to its essential role in the virus life cycle. Here, we outline recent progress in studies on the Zika protease. Biochemical, biophysical, and structural studies on different protease constructs provide new insight into the structure and activity of the protease. The unlinked construct displays higher enzymatic activity and better mimics the native state of the enzyme and therefore is better suited for drug discovery. Furthermore, the structure of the free enzyme adopts a closed conformation and a preformed active site. The availability of a lead fragment hit and peptide inhibitors, as well as the attainability of soakable crystals, suggest that the unlinked construct is a promising tool for drug discovery.
ISSN: 0966-842X
DOI: 10.1016/j.tim.2017.07.001
Rights: © 2017 Elsevier Ltd. All rights reserved. This paper was published in Trends in Microbiology and is made available with permission of Elsevier Ltd.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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