Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140786
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dc.contributor.authorKang, CongBaoen_US
dc.contributor.authorKeller, Thomas H.en_US
dc.contributor.authorLuo, Dahaien_US
dc.date.accessioned2020-06-02T03:31:43Z-
dc.date.available2020-06-02T03:31:43Z-
dc.date.issued2017-
dc.identifier.citationKang, C., Keller, T. H., & Luo, D. (2017). Zika virus protease : an antiviral drug target. Trends in Microbiology, 25(10), 797-808. doi:10.1016/j.tim.2017.07.001en_US
dc.identifier.issn0966-842Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/140786-
dc.description.abstractThe recent outbreak of Zika virus (ZIKV) infection has caused global concern due to its link to severe damage to the brain development of foetuses and neuronal complications in adult patients. A worldwide research effort has been undertaken to identify effective and safe treatment and vaccination options. Among the proposed viral and host components, the viral NS2B-NS3 protease represents an attractive drug target due to its essential role in the virus life cycle. Here, we outline recent progress in studies on the Zika protease. Biochemical, biophysical, and structural studies on different protease constructs provide new insight into the structure and activity of the protease. The unlinked construct displays higher enzymatic activity and better mimics the native state of the enzyme and therefore is better suited for drug discovery. Furthermore, the structure of the free enzyme adopts a closed conformation and a preformed active site. The availability of a lead fragment hit and peptide inhibitors, as well as the attainability of soakable crystals, suggest that the unlinked construct is a promising tool for drug discovery.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofTrends in Microbiologyen_US
dc.rights© 2017 Elsevier Ltd. All rights reserved. This paper was published in Trends in Microbiology and is made available with permission of Elsevier Ltd.en_US
dc.subjectScience::Medicineen_US
dc.titleZika virus protease : an antiviral drug targeten_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationNTU Institute of Structural Biologyen_US
dc.identifier.doi10.1016/j.tim.2017.07.001-
dc.description.versionAccepted versionen_US
dc.identifier.pmid28789826-
dc.identifier.scopus2-s2.0-85026819700-
dc.identifier.issue10en_US
dc.identifier.volume25en_US
dc.identifier.spage797en_US
dc.identifier.epage808en_US
dc.subject.keywordsFlavivirusen_US
dc.subject.keywordsProtease Inhibitoren_US
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Appears in Collections:LKCMedicine Journal Articles
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