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Title: Glucose-responsive peptide coacervates with high encapsulation efficiency for controlled release of insulin
Authors: Lim, Zhi Wei
Ping, Yuan
Miserez, Ali
Keywords: Engineering::Materials
Issue Date: 2018
Source: Lim, Z. W., Ping, Y., & Miserez, A. (2018). Glucose-responsive peptide coacervates with high encapsulation efficiency for controlled release of insulin. Bioconjugate Chemistry, 29(7), 2176-2180. doi:10.1021/acs.bioconjchem.8b00369
Journal: Bioconjugate Chemistry
Abstract: A new glucose-responsive insulin delivery system is fabricated using biomimetic peptide coacervates derived from the Humboldt squid (Dosidicus Gigas) beak. Both insulin and glucose oxidase are coencapsulated within coacervate microdroplets. The glucose oxidase quickly responds to increasing glucose levels to generate a local acidic environment, thereby rapidly triggering the dissociation of pH-sensitive coacervates to release the insulin cargo. The rate of insulin release is dependent on the glucose level, increases under hyperglycemic conditions, and decreases under normoglycemic conditions. This glucose responsiveness mimics pancreatic β-cell function by releasing insulin according to glucose levels.
ISSN: 1043-1802
DOI: 10.1021/acs.bioconjchem.8b00369
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Bioconjugate Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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