Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140820
Title: Petasis/Diels-Alder/cyclization cascade reactions for the generation of scaffolds with multiple stereogenic centers and orthogonal handles for library production
Authors: Flagstad, Thomas
Azevedo, Carlos M. G.
Min, Geanna
Willaume, Anthony
Morgentin, Rémy
Nielsen, Thomas E.
Clausen, Mads Hartvig
Keywords: Engineering::Environmental engineering
Issue Date: 2018
Source: Flagstad, T., Azevedo, C. M. G., Min, G., Willaume, A., Morgentin, R., Nielsen, T. E., & Clausen, M. H. (2018). Petasis/Diels-Alder/cyclization cascade reactions for the generation of scaffolds with multiple stereogenic centers and orthogonal handles for library production. European Journal of Organic Chemistry, 2018(36), 5023-5029. doi:10.1002/ejoc.201800565
Journal: European Journal of Organic Chemistry
Abstract: A new effective strategy for the synthesis of sp3-rich small molecules for library production is presented. The key steps to generate complexity involve a Petasis three-component reaction followed by an intramolecular Diels–Alder and cyclization to generate a densely enriched tricyclic or tetracyclic scaffolds with 3–4 stereocenters and three handles for decoration. The strategy was used for the production of 143 molecules for the European Lead Factory.
URI: https://hdl.handle.net/10356/140820
ISSN: 1434-193X
DOI: 10.1002/ejoc.201800565
Rights: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCELSE Journal Articles

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