Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/140923
Title: Adaptation of Plasmodium falciparum to its transmission environment
Authors: Rono, Martin K.
Nyonda, Mary A.
Simam, Joan J.
Ngoi, Joyce M.
Mok, Sachel
Kortok, Moses M.
Abdullah, Abdullah S.
Elfaki, Mohammed M.
Waitumbi, John N.
El-Hassan, Ibrahim M.
Marsh, Kevin
Bozdech, Zbynek
Mackinnon, Margaret J.
Keywords: Science::Biological sciences
Issue Date: 2017
Source: Rono, M. K., Nyonda, M. A., Simam, J. J., Ngoi, J. M., Mok, S., Kortok, M. M., . . . Mackinnon, M. J. (2018). Adaptation of Plasmodium falciparum to its transmission environment. Nature Ecology and Evolution, 2(2), 377-387. doi:10.1038/s41559-017-0419-9
Journal: Nature Ecology and Evolution
Abstract: Success in eliminating malaria will depend on whether parasite evolution outpaces control efforts. Here, we show that Plasmodium falciparum parasites (the deadliest of the species causing human malaria) found in low-transmission-intensity areas have evolved to invest more in transmission to new hosts (reproduction) and less in within-host replication (growth) than parasites found in high-transmission areas. At the cellular level, this adaptation manifests as increased production of reproductive forms (gametocytes) early in the infection at the expense of processes associated with multiplication inside red blood cells, especially membrane transport and protein trafficking. At the molecular level, this manifests as changes in the expression levels of genes encoding epigenetic and translational machinery. Specifically, expression levels of the gene encoding AP2-G-the transcription factor that initiates reproduction-increase as transmission intensity decreases. This is accompanied by downregulation and upregulation of genes encoding HDAC1 and HDA1-two histone deacetylases that epigenetically regulate the parasite's replicative and reproductive life-stage programmes, respectively. Parasites in reproductive mode show increased reliance on the prokaryotic translation machinery found inside the plastid-derived organelles. Thus, our dissection of the parasite's adaptive regulatory architecture has identified new potential molecular targets for malaria control.
URI: https://hdl.handle.net/10356/140923
ISSN: 2397-334X
DOI: 10.1038/s41559-017-0419-9
Rights: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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