Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/141155
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFoo, Jia Neeen_US
dc.contributor.authorXia, Yunen_US
dc.date.accessioned2020-06-04T08:04:23Z-
dc.date.available2020-06-04T08:04:23Z-
dc.date.issued2019-
dc.identifier.citationFoo, J. N., & Xia, Y. (2019). Polycystic kidney disease : new knowledge and future promises. Current Opinion in Genetics & Development, 56, 69-75. doi:10.1016/j.gde.2019.06.007en_US
dc.identifier.issn0959-437Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/141155-
dc.description.abstractPolycystic kidney disease (PKD) is one of the most common genetic kidney diseases, characterized by the formation of fluid-filled renal cysts, which eventually lead to end-stage renal disease. Despite several decades of investigation, explicit molecular and cellular mechanisms underpinning renal cyst formation have been unresolved until recently, severely hampering the development of effective therapeutic approaches. Currently, most PKD therapies have been developed for limiting disease complications, such as hypertension. Although Tolvaptan has been approved for treating PKD in few countries, the associated hepatic toxicity remains a major concern. In this Review, we will discuss recent advances in PKD research, covering aspects ranging from newly identified genetic/epigenetic causes, increment in mechanistic interpretation, novel therapeutic targets, to the promises offered by emerging stem cell technologies.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofCurrent Opinion in Genetics & Developmenten_US
dc.rights© 2019 Elsevier Ltd. All rights reserved. This paper was published in Current Opinion in Genetics & Development and is made available with permission of Elsevier Ltd.en_US
dc.subjectScience::Medicineen_US
dc.titlePolycystic kidney disease : new knowledge and future promisesen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1016/j.gde.2019.06.007-
dc.description.versionAccepted versionen_US
dc.identifier.volume56en_US
dc.identifier.spage69en_US
dc.identifier.epage75en_US
dc.subject.keywordsKidney Dysfunctionen_US
dc.subject.keywordsDevelopmental Biologyen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:LKCMedicine Journal Articles
Files in This Item:
File Description SizeFormat 
Polycystic kidney disease.pdf259.81 kBAdobe PDFThumbnail
View/Open

Page view(s)

111
Updated on Jan 24, 2022

Download(s) 50

100
Updated on Jan 24, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.